diABZI STING agonist-1

diABZI STING agonist-1 is an agonist of the stimulator of interferon genes (STING) pathway.¹ It induces secretion of IFN-β in human peripheral blood mononuclear cells (PBMCs; EC₅₀ = 130 nM). diABZI STING agonist-1 (2.5 mg/kg) increases serum levels of IFN-β, IL-6, TNF, and KC/GROα in wild-type, but not Sting-/-, mice. It inhibits the cytopathic effect of the common cold human coronavirus 229E (HCoV-229E) in infected MRC-5 cells (EC₅₀ = 3 nM). diABZI STING agonist-1 also decreases the level of severe acute respiratory coronavirus 2 (SARS-CoV-2) RNA in primary human bronchial airway epithelial cells in an air-liquid interface assay.² It decreases tumor volume and increases survival in a CT26 murine colorectal cancer model when administered at a dose of 3 mg/kg.

1.Ramanjulu, J.M., Pesiridis, G.S., Yang, J., et al.Design of amidobenzimidazole STING receptor agonists with systemic activityNature564(7736)439-443(2018) 2.Zhu, Q., Zhang, Y., Wang, L., et al.Inhibition of coronavirus infection by a synthetic STING agonist in primary human airway systemAntiviral Res.187105015(2021)