Dracorhodin perchlorate
(Synonyms: 血竭素高氯酸盐; Dracohodin perochlorate) 目录号 : GC35898
A pro-apoptotic compound
Cas No.:125536-25-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Dracorhodin perchlorate is a pro-apoptotic compound and a synthetic analog of dracorhodin, an anthocyanin that has been found in D. draco fruit.1,2 It induces cell cycle arrest at the G0/G1 phase as well as apoptosis in U87MG and T98G glioma cells when used at concentrations of 40 and 80 μM.2 It also increases levels of p53, p21, Bim, and Bax and decreases levels of Bcl-2 in glioma cells in vitro. Dracorhodin perchlorate is cytotoxic to U937, A375-S2, and MCF-7 cells in a concentration-dependent manner.1 It is also cytotoxic to HeLa cells, an effect that can be reversed by Ac-YVAD-CMK , Z-DEVD-FMK , Z-IETD-FMK, and Z-LEHD-FMK, which are inhibitors of caspase-1, -3, -8, and -9, respectively.
1.Xia, M., Wang, D., Wang, M., et al.Dracorhodin perchlorate induces apoptosis via activation of caspases and generation of reactive oxygen speciesJ. Pharmacol. Sci.95(2)273-283(2004) 2.Chen, X., Luo, J., Meng, L., et al.Dracorhodin perchlorate induces the apoptosis of glioma cellsOncol. Rep.35(4)2364-2372(2016)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.7267 mL | 13.6333 mL | 27.2665 mL |
| 5 mM | 0.5453 mL | 2.7267 mL | 5.4533 mL |
| 10 mM | 0.2727 mL | 1.3633 mL | 2.7267 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。