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Endoxifen Z-isomer hydrochloride Sale

(Synonyms: Z-因多昔芬盐酸盐) 目录号 : GC35991

Endoxifen HCl, the active metabolite of Tamoxifen, ia a potent and selective estrogen receptor antagonist. Phase 2.

Endoxifen Z-isomer hydrochloride Chemical Structure

Cas No.:1032008-74-4

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥638.00
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1mg
¥324.00
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5mg
¥576.00
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10mg
¥765.00
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50mg 待询 待询
100mg 待询 待询

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产品描述

Endoxifen HCl, the active metabolite of Tamoxifen, ia a potent and selective estrogen receptor antagonist. Phase 2.

Endoxifen shows anti-estrogenic effects, and decreases the E2-induced PR expression in MCF-7 cells. [1] Endoxifen also blocks ER-alpha transcriptional activity and inhibits estrogen-induced breast cancer cell proliferation. [2] In MCF7, HS 578T, and BT-549 cells, Endoxifen significantly inhibits cell proliferation. [3] Endoxifen also exhibits four-fold higher inhibition on PKC activity compared to tamoxifen. [4] Endoxifen inhibits the hERG current by preferentially interacting with the activated states of cloned hERG potassium channels with IC50 of 1.6 μM. [5]

In vivo, Endoxifen (8 mg/kg, ) inhibits growth of MCF-7 human mammary tumor xenografts in mice, showing more potency than Tamoxifen. [3]

[1] Lim YC, et al. Cancer Chemother Pharmacol. 2005, 55(5), 471-478. [2] Wu X, et al. Cancer Res. 2009, 69(5), 1722-1727. [3] Ahmad A, et al. Breast Cancer Res Treat. 2010, 122(2), 579-584.

Chemical Properties

Cas No. 1032008-74-4 SDF
别名 Z-因多昔芬盐酸盐
Canonical SMILES OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)\CC)C=C1.[H]Cl.[Z]
分子式 C25H28ClNO2 分子量 409.95
溶解度 DMSO: 12.5 mg/mL (30.49 mM); Water: < 0.1 mg/mL (insoluble) 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.4393 mL 12.1966 mL 24.3932 mL
5 mM 0.4879 mL 2.4393 mL 4.8786 mL
10 mM 0.2439 mL 1.2197 mL 2.4393 mL
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