Eupatorin

Eupatorin is a flavonoid that has been found in L. camara and has diverse biological activities.^1,2,3,4 It inhibits the growth of HeLa, MK-1, and B16/F10 tumor cells (GI₅₀s = 15, 58, and 44 ?M, respectively).¹ Eupatorin is active against T. cruzi epimastigotes and trypomastigotes (IC₅₀s = 0.2 and 61.8 ?g/ml, respectively) without inducing cytotoxicity in Vero cells (IC₅₀ = >500 ?g/ml).² It induces vasorelaxation in isolated rat thoracic aortic rings precontracted with phenylephrine (pD₂ = 6.66).³ Eupatorin (10 and 100 ?M) reduces nuclear translocation of NF-κB and STAT1α in J774 murine macrophages and reduces paw edema in a mouse model of carrageenan-induced paw inflammation when administered at a dose of 50 mg/kg.⁴

1.Nagao, T., Abe, F., Kinjo, J., et al.Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationshipBiol. Pharm. Bull.25(7)875-879(2002) 2.Beer, M.F., Frank, F.M., Germán Elso, O., et al.Trypanocidal and leishmanicidal activities of flavonoids isolated from Stevia satureiifolia var. satureiifoliaPharm. Biol.54(10)2188-2195(2016) 3.Yam, M.F., Tan, C.S., Ahmad, M., et al.Mechanism of vasorelaxation induced by eupatorin in the rats aortic ringEur. J. Pharmacol.78927-36(2016) 4.Laavola, M., Nieminen, R., Yam, M.F., et al.Flavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activationPlanta Med.78(8)779-786(2012)