Ganoderenic acid A
(Synonyms: 灵芝烯酸 A) 目录号 : GC36112
A triterpenoid
Cas No.:100665-40-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Ganoderenic acid A is a triterpenoid originally isolated from G. lucidum that has enzyme inhibitory activities.1,2,3 It is an inhibitor of β-glucuronidase (IC50 = 0.12 mg/ml in rat liver microsomes).2 Ganoderenic acid A (100 mg/kg) reduces increases in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) in a rat model of liver injury induced by carbon tetrachloride (CCl4). It also inhibits aldose reductase by 54.2% when used at a concentration of 100 ?g/ml.3
1.Komoda, Y., Nakamura, H., Ishihara, S., et al.Structures of new terpenoid constituents of Ganoderma lucidum (Fr.) KARST (Polyporaceae)Chem. Pharm. Bull.33(11)4829-4835(1985) 2.Kim, D.-H., Shim, S.-B., Kim, N.-J., et al.β-Glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidumBiol. Pharm. Bull.22(2)162-164(1999) 3.Fatmawati, S., Shimizu, K., and Kondo, R.Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidumPlanta Med.76(15)1691-1693(2010)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 1.9431 mL | 9.7153 mL | 19.4307 mL |
| 5 mM | 0.3886 mL | 1.9431 mL | 3.8861 mL |
| 10 mM | 0.1943 mL | 0.9715 mL | 1.9431 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。