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Hypocrellin A Sale

(Synonyms: 竹红菌甲素) 目录号 : GC36282

A perylenequinoid with diverse biological activities

Hypocrellin A Chemical Structure

Cas No.:77029-83-5

规格 价格 库存 购买数量
5 mg
¥1,350.00
现货
10 mg
¥2,160.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

Hypocrellin A is a perylenequinoid that has been found in Shiraia bambusicola and has diverse biological activities.1,2 It is active against C. albicans, C. parapsilosis, and C. tropicalis fungi (IC50s = 0.65, 1, and 85 ?g/ml, respectively), as well as S. aureus, methicillin-resistant S. aureus (MRSA), P. aeruginosa, and M. intracellulare bacteria (IC50s = 3, 7, 10, and 2.5 ?g/ml, respectively).1 Hypocrellin A is also active against L. donovani promastigotes (IC50 = 0.27 ?g/ml). Upon photoactivation with UV radiation, hypocrellin A induces production of reactive oxygen species and apoptosis and reduces cell viability of A549 cancer cells.2

1.Ma, G., Khan, S.I., Jacob, M.R., et al.Antimicrobial and antileishmanial activities of hypocrellins A and BAntimicrob. Agents Chemother.48(11)4450-4452(2004) 2.Qi, S., Guo, L., Yan, S., et al.Hypocrellin A-based photodynamic action induces apoptosis in A549 cells through ROS-mediated mitochondrial signaling pathwayActa Pharm. Sin. B.9(2)279-293(2019)

化学性质

Cas No. 77029-83-5 SDF
别名 竹红菌甲素
Canonical SMILES COC(C1=O)=C2C3=C(C1=C(C=C4OC)O)C4=C(C(OC)=CC(O)=C56)C5=C3C(CC(C)(O)C2C(C)=O)=C(OC)C6=O
分子式 C30H26O10 分子量 546.52
溶解度 DMF: 2mg/mL,DMSO: 3mg/mL,Ethanol: 0.3mg/mL 储存条件 4°C, protect from light
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 1.8298 mL 9.1488 mL 18.2976 mL
5 mM 0.366 mL 1.8298 mL 3.6595 mL
10 mM 0.183 mL 0.9149 mL 1.8298 mL
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