InteriotherinA
(Synonyms: 内南五味子酯A) 目录号 : GC36320
Interiotherin A 是具有从 Kadsura 内部分离的含二苯并环辛二烯骨架的木脂素。 Interiotherin A 抑制 HIV 复制并且表现出抗 HIV 活性，它具有代谢产物和抗 HIV 的作用。
Cas No.:181701-06-4
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Interiotherin A is a lignan with a dibenzocyclooctadiene skeleton isolated from Kadsura interior. Interiotherin A inhibits HIV replication to exhibit anti-HIV activity, it has a role as a metabolite and an anti-HIV agent[1].
Interiotherin A (Compounds 1) (0.8-100µg/mL; 4 hours) inhibits HIV replication with EC50 values of 3.1 µg/mL[1]. Cell Cytotoxicity Assay[1] Cell Line: T cell line: HS1
[1]. Chen DF, et al. Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior. J Nat Prod. 1996 Nov;59(11):1066-8.
| Cas No. | 181701-06-4 | SDF | |
| 别名 | 内南五味子酯A | ||
| Canonical SMILES | COC1=C2C3=C(CC(C)C(C)C(OC(C4=CC=CC=C4)=O)C2=CC5=C1OCO5)C=C(OCO6)C6=C3OC | ||
| 分子式 | C29H28O8 | 分子量 | 504.53 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.982 mL | 9.9102 mL | 19.8204 mL |
| 5 mM | 0.3964 mL | 1.982 mL | 3.9641 mL |
| 10 mM | 0.1982 mL | 0.991 mL | 1.982 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Asymmetric synthesis of the dibenzocyclooctadiene lignans Interiotherin A and gomisin R
Org Lett 2005 Apr 28;7(9):1849-52.PMID:15844922DOI:10.1021/ol050476t.
[structure: see text] Asymmetric total syntheses of the dibenzocyclooctadiene lignans Interiotherin A and angeloylgomisin R are reported. The syntheses were based on an atropdiastereoselective, copper-promoted biaryl coupling reaction, a diastereoselective hydroboration/Suzuki-Miyaura coupling reaction sequence, and an asymmetric boron-mediated tiglylation of an aryl aldehyde precursor.
Chemical analysis of twelve lignans in the fruit of Schisandra sphenanthera by HPLC-PAD-MS
Phytomedicine 2012 Oct 15;19(13):1234-41.PMID:22906629DOI:10.1016/j.phymed.2012.07.017.
The fruit of S. sphenanthera, known as "Nanwuweizi", has been widely used as traditional Chinese medicine for several thousand years. However, the current determination methods are not sufficient to evaluate its quality. An accurate, sensitive and reliable high performance liquid chromatography coupled with photodiode array detection and mass spectrum (HPLC-PAD-MS) was developed for quantitative analysis of twelve lignans (schisandrol A, schisandrol B, gomisin G, schisantherin A, schisantherin D, schisanhenol, (+)-anwulignan, deoxyschisandrin, schisandrin B, schisandrin C, 6-O-benzoylgomisin O, and Interiotherin A) in the fruit of S. sphenanthera. The chromatographic conditions and extraction procedures were optimized during the study. The identity of chromatographic peaks in the sample HPLC profiles was confirmed by comparing the retention time, ultraviolet (UV) spectra and MS data with reference compounds. The validated method was successfully used to determine the twelve lignans in the samples collected from different localities in China. The hierarchical clustering analysis (HCA) and principal components analysis (PCA) were successfully applied to the data of twelve lignans from the HPLC profiles in sixteen batches of the fruit of S. sphenanthera to discriminate the samples with different sources. Moreover, the results of the loading plot of the PCA indicated that schisantherin A, (+)-anwulignan, and deoxyshisandrin were found to be the main constituents in the fruit of S. sphenanthera, and which could be chosen as the chemical markers for evaluate the quality of the fruit of S. sphenanthera. The results indicated that the developed method was readily utilized as a quality evaluation method for the fruit of S. sphenanthera.
Asymmetric total synthesis of dibenzocyclooctadiene lignan natural products
J Org Chem 2005 Oct 28;70(22):8932-41.PMID:16238330DOI:10.1021/jo051525i.
[structure: see text] Full details of the asymmetric total syntheses of the dibenzocyclooctadiene lignans Interiotherin A, angeloylgomisin R, gomisin O, and gomisin E (epigomisin O) are presented. The syntheses were based on a unified synthetic strategy involving a novel crotylation using the Leighton auxiliary that occurred with excellent asymmetric induction (>98:2 enantiomeric ratio), a diastereoselective hydroboration/Suzuki-Miyaura coupling reaction sequence, and an atropdiastereoselective biarylcuprate coupling, both of which occurred with total (>20:1) stereocontrol. The syntheses were achieved in six to eight steps from simple aromatic precursors.
Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation
J Nat Prod 2002 Sep;65(9):1242-5.PMID:12350139DOI:10.1021/np0105127.
Two new lignans, interiotherins C (1) and D (2), together with the known compounds interiorin (3), heteroclitin F (4), neokadsuranin (5), heteroclitin D (6), kadsurin (7), gomisin A (8), schisandrin C (9), Interiotherin A (10), angeloylgomisin R (11), gomisin G (12), interiotherin B (13), and gomisin C (14), were isolated from the stems of Kadsura interior. The structures and stereochemistries of the new compounds were determined from mass, CD, and NMR spectral data. Fourteen neolignans were screened as potential antitumor promoters by examining their ability to inhibit Epstein-Barr virus early antigen (EBV-EA) activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. Neokadsuranin (5) and schisandrin C (9) were the most potent compounds. These data suggest that some neolignans might be valuable antitumor promoters or chemopreventors.
[Chemical constituents of petroleum ether extract of fruits of Schisandra sphenanthera]
Zhongguo Zhong Yao Za Zhi 2012 Jun;37(11):1597-601.PMID:22993989doi
Objective: To study the chemical constituents in the fruits of Schisandra sphenanthera. Method: The constituents were isolated by their silica gel column, Sephadex LH-20 gel column, and their structures were elucidated by their chemical properties and spectroscopic analyses. Result: Twelve compounds were isolated and identified as (+)-anwulignan (1), deoxyschizandrin (2), Interiotherin A (3), schisantherin A (4), beta-sitosterol (5), schisantherin D (6), 4-hydroxybenzaldehyde (7), 6-O-benzoylgomisin O (8), schizandronic acid (9), schisanlactone D (10), schisanlactone B (11), kadsulactone A (12). Conclusion: Compounds 3, 7, 10-12 were obtained from this plant for the first time.