Ipfencarbazone
(Synonyms: 三唑酰草胺) 目录号 : GC36325
Ipfencarbazone 是一种除草剂，用于控制杂草如水稻中的水草。
Cas No.:212201-70-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Ipfencarbazone is a substance being developed for the control of weeds such as watergrass in rice; herbicide agent.
| Cas No. | 212201-70-2 | SDF | |
| 别名 | 三唑酰草胺 | ||
| Canonical SMILES | O=C(N1C=NN(C2=CC=C(Cl)C=C2Cl)C1=O)N(C3=CC=C(F)C=C3F)C(C)C | ||
| 分子式 | C18H14Cl2F2N4O2 | 分子量 | 427.23 |
| 溶解度 | DMSO: 130 mg/mL (304.29 mM); Water: < 0.1 mg/mL (insoluble) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.3407 mL | 11.7033 mL | 23.4066 mL |
| 5 mM | 0.4681 mL | 2.3407 mL | 4.6813 mL |
| 10 mM | 0.2341 mL | 1.1703 mL | 2.3407 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Characterization of very long chain fatty acid synthesis inhibition by Ipfencarbazone
J Pestic Sci 2019 Feb 20;44(1):20-24.PMID:30820169DOI:10.1584/jpestics.D18-057.
Ipfencarbazone exhibits excellent herbicidal activity against Echinochloa spp. and is safe for rice. The effects of Ipfencarbazone on very long chain fatty acid (VLCFA) elongation in rice and late watergrass and its inhibitory mechanism were investigated in this study. Although Ipfencarbazone inhibited VLCFA elongation in the microsomes prepared from late watergrass and rice at low concentrations, the inhibitory effect was higher in late watergrass than in rice. These results suggested that the primary site of action of Ipfencarbazone is VLCFA elongase (VLCFAE) and Ipfencarbazone has a differential affinity between the VLCFAEs of the plants. The inhibitory activity of Ipfencarbazone became higher in proportion to pre-incubation period with the VLCFAE. The degree of inhibition did not decrease by dilution of the VLCFAE-ipfencarbazone complex. These results suggested that Ipfencarbazone binds to the VLCFAE irreversibly.
Development of a rice herbicide, Ipfencarbazone
J Pestic Sci 2016 Aug 20;41(3):113-119.PMID:30363120DOI:10.1584/jpestics.J16-06.
Hokko Chemical Industry Co., Ltd. found a novel triazolinone class herbicide regarded as 1-aryl-4-carbamoyl-1,2,4-triazolinone derivatives that shows high level of safety to paddy rice, and high activity and long residual activity against Echinochloa spp. and other weeds. We selected a new paddy rice herbicide Ipfencarbazone as the optimum compound. Ipfencarbazone is a pre-emergence and early post-emergence rice herbicide that controls annual grass weeds, annual sedge weeds and some annual broadleaf weeds at a rate of 250 g a.i./ha. It inhibits the biosynthesis of fatty acids in plants (VLCFA). Two formulations containing Ipfencarbazone, Winner® and Fighter®, have been registered in Japan since 2013 and various combinations have been launched.
Effects of environmental factors on the herbicidal activity and phytotoxicity of Ipfencarbazone
J Pestic Sci 2018 Nov 20;43(4):255-260.PMID:30479546DOI:10.1584/jpestics.D18-024.
Ipfencarbazone exhibits excellent herbicidal activity against Echinochloa spp. and is safe for transplanted rice at a dose of 250 g a.i./ha. However, the effect of various environmental factors on its activity has not been verified. The present study evaluated the factors affecting the herbicidal activity of Ipfencarbazone against Echinochloa spp. and its phytotoxicity to transplanted rice. The herbicidal activity and phytotoxicity of Ipfencarbazone were barely affected by temperature, soil texture, water leakage, or flooding water depth. When an overflow was conducted artificially 6 hr after application, the herbicidal activity was stable. Furthermore, Ipfencarbazone completely inhibited the emergence of Echinochloa spp. for 56 days regardless of the soil texture, water leakage and overflow conditions. When the period between application and reflooding was within 24 hr of herbicide application, the phytotoxicity of Ipfencarbazone on transplanted rice was slight. These results suggest that Ipfencarbazone shows stable efficacy in practical use.
Analytical method development, validation and study on behaviour of Ipfencarbazone in paddy (rice)
Environ Sci Pollut Res Int 2023 Feb;30(7):18810-18819.PMID:36219283DOI:10.1007/s11356-022-23413-x.
Supervised field trial was conducted to study persistence of a pre-emergent herbicide, Ipfencarbazone (25% SC) on rice crop. Single application of two different doses, 156.25 g a.i.ha-1/625 mL formulationha-1 and 312.50 g a.i.ha-1/1250 mL formulationha-1, was applied. Method was validated to analyse Ipfencarbazone in rice samples (leaf/plant, grain, straw and husk) and in soil. Initial accumulation of Ipfencarbazone in rice plants was 6.72 and 14.71 mg kg-1 in standard and double dose, respectively. The residues decreased linearly with r2 values of 0.92 and 0.98 in different doses and reached below limit of quantitation (LOQ) of 0.01 μg kg-1 (for rice plant/leaf) and 0.05 μg kg-1 (for rice grain, husk, straw) on 30th and 97th (harvest) day respectively after application in both the doses. An average half-life of Ipfencarbazone was approximately 4 days. Less than LOQ levels at harvest and short half-life suggest that the use of Ipfencarbazone is safe, provided good agricultural practices (GAP) are followed. The data can be used by regulatory authorities like Food Safety and Standards Authority of India (FSSAI) and CODEX for establishing maximum residue limits (MRLs) of Ipfencarbazone.
[Development of Determination Method of Ipfencarbazone in Agricultural Products, Livestock Products and Seafood by LC-MS/MS]
Shokuhin Eiseigaku Zasshi 2015;56(5):205-10.PMID:26537650DOI:10.3358/shokueishi.56.205.
A method for the determination of Ipfencarbazone in agricultural products, livestock products and seafood by LC-MS/MS was developed. Agricultural samples were extracted with acetone. An aliquot of crude extract was partitioned with n-hexane and sat. sodium chloride solution. Clean-up was performed using GC/PSA and C18 cartridges. In the case of livestock products and seafood, samples were extracted with a mixture of acetone and n-hexane, and the organic layer was collected. After acetonitrile-hexane partitioning, the extract was cleaned up using PAS and C18 cartridges. The gradient LC separation was performed on a C18 column with acetonitrile-water containing acetic acid as a mobile phase, and MS with positive ion electrospray ionization was used for detection. The average recoveries (n=5) of Ipfencarbazone from 16 kinds of agricultural products, livestock products and seafood spiked at the MRLs or at the uniform limits (0.01 ppm) were 73-101%, and the relative standard deviations were 1.3-5.1%. The limit of quantitation of the developed method was 0.01 mg/kg for Ipfencarbazone.