Lasalocid sodium
(Synonyms: 拉沙洛西钠; Lasalocid-A sodium; Ionophore X-537A sodium; Antibiotic X-537A sodium) 目录号 : GC36427
An ionophore antibiotic
Cas No.:25999-20-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Lasalocid is a polyketide-synthase derived ionophore antibiotic originally isolated from S. lasaliensis.1,2 It binds to monovalent and divalent cations, including potassium, sodium, calcium, and magnesium cations.3 Lasalocid (0.01 and 0.1 ?g/ml) is active against E. tenella.4 In vivo, lasalocid (125 ppm in the feed) reduces the severity of gastrointestinal lesions in chicks experimentally infected with E. tenella, E. maxima, E. necatrix, E. brunetti, or E. acervulina. It has been found in groundwater.5 Formulations containing lasalocid have been used in the treatment of coccidiosis in poultry.
1.Migita, A., Watanabe, M., Hirose, Y., et al.Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensisBiosci. Biotechnol. Biochem.73(1)169-176(2009) 2.Mitrovic, M., and Schildknecht, E.G.Anticoccidial activity of lasalocid (X-537A) in chicksPoult. Sci.53(4)1448-1455(1974) 3.Antonenko, Y.N., and Yaguzhinsky, L.S.The ion selectivity of nonelectrogenic ionophores measured on a bilayer lipid membrane: nigericin, monensin, A23187 and lasalocid ABiochim. Biophys. Acta938(2)125-130(1988) 4.Folz, S.D., Lee, B.L., Nowakowski, L.H., et al.Anticoccidial evaluation of halofuginone, lasalocid, maduramicin, monensin and salinomycinVet. Parasitol.28(1-2)1-9(1988) 5.Mooney, D., Richards, K.G., Danaher, M., et al.An investigation of anticoccidial veterinary drugs as emerging organic contaminants in groundwaterSci. Total Environ.746141116(2020)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 1.6319 mL | 8.1597 mL | 16.3193 mL |
| 5 mM | 0.3264 mL | 1.6319 mL | 3.2639 mL |
| 10 mM | 0.1632 mL | 0.816 mL | 1.6319 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。