Luteolin 7-O-glucuronide
(Synonyms: 木犀草素-7-葡萄糖醛酸苷,Luteolin 7-glucuronide) 目录号 : GC36495
A flavone with diverse biological activities
Cas No.:29741-10-4
Sample solution is provided at 25 µL, 10mM.
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Luteolin 7-O-glucuronide is a flavonoid that has been found in S. chloroleuca and A. pilosa, and has diverse biological activities, including antioxidant, enzyme inhibitory, and anti-inflammatory properties.1,2,3 It scavenges DPPH radicals in a cell-free assay (IC50 = 80.6 μM).1 Luteolin 7-O-Glucuronide inhibits porcine α-amylase and yeast α-glucosidase in vitro (IC50s = 61.5 and 14.7 μM, respectively).3 It also inhibits rat aldose reductase in vitro (IC50 = 0.7 μM) and sorbitol accumulation in isolated rat lens by 91.8% when used at a concentration of 5 μg/ml.1 Luteolin 7-O-glucuronide inhibits LPS-induced cytokine release from RAW 264.7 macrophages in a dose-dependent manner.2
1.Kim, S.B., Hwang, S.H., Suh, H.-W., et al.Phytochemical analysis of Agrimonia pilosa Ledeb, its antioxidant activity and aldose reductase inhibitory potentialInt. J. Mol. Sci.18(2)379(2017) 2.Cho, Y.-C., Park, J., and Cho, S.Anti-inflammatory and anti-oxidative effects of luteolin-7-O-glucuronide in LPS-stimulated murine macrophages through TAK1 inhibition and Nrf2 activationInt. J. Mol. Sci.21(6)2007(2020) 3.Asghari, B., Salehi, P., Sonboli, A., et al.Flavonoids from Salvia chloroleuca with α-amylsae and α-glucosidase inhibitory effectIran. J. Pharm. Res.14(2)609-615(2015)
| Cas No. | 29741-10-4 | SDF | |
| 别名 | 木犀草素-7-葡萄糖醛酸苷,Luteolin 7-glucuronide | ||
| Canonical SMILES | O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC(O)=C3C(C=C(C4=CC=C(O)C(O)=C4)OC3=C2)=O | ||
| 分子式 | C21H18O12 | 分子量 | 462.36 |
| 溶解度 | DMSO: 130 mg/mL (281.17 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.1628 mL | 10.8141 mL | 21.6282 mL |
| 5 mM | 0.4326 mL | 2.1628 mL | 4.3256 mL |
| 10 mM | 0.2163 mL | 1.0814 mL | 2.1628 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet