Luteolin-3-O-beta-D-glucuronide
(Synonyms: 木犀草素-3'-葡萄糖醛酸苷) 目录号 : GC36496
Luteolin-3-O-beta-D-glucuronide 是一种木犀草素葡萄糖醛酸，木犀草素的 3’ 端位置有 β-d-葡萄糖苷酸残基。
Cas No.:53527-42-7
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Luteolin-3-O-beta-D-glucuronide is a luteolin glucosiduronic acid consisting of luteolin having a beta-D-glucosiduronic acid residue attached at the 3'-position.
| Cas No. | 53527-42-7 | SDF | |
| 别名 | 木犀草素-3'-葡萄糖醛酸苷 | ||
| Canonical SMILES | O=C1C2=C(O)C=C(O)C=C2OC(C3=CC(O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)C(O)=O)=C(O)C=C3)=C1 | ||
| 分子式 | C21H18O12 | 分子量 | 462.36 |
| 溶解度 | DMSO : 100 mg/mL (216.28 mM; Need ultrasonic) | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.1628 mL | 10.8141 mL | 21.6282 mL |
| 5 mM | 0.4326 mL | 2.1628 mL | 4.3256 mL |
| 10 mM | 0.2163 mL | 1.0814 mL | 2.1628 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Luteolin 3'-glucuronide, the major flavonoid from Melissa officinalis subsp. officinalis
Fitoterapia 2000 Apr;71(2):201-2.PMID:10727822DOI:10.1016/s0367-326x(99)00118-5.
luteolin 3'-O-beta-D-glucuronide (1) was isolated from the leaves of Melissa officinalis subsp. officinalis and characterized by spectroscopic analysis.
Flavonoids and phenolic compounds from Rosmarinus officinalis
J Agric Food Chem 2010 May 12;58(9):5363-7.PMID:20397728DOI:10.1021/jf100332w.
A new flavonoid, 6''-O-(E)-feruloylhomoplantaginin (1), and 14 known compounds, 6''-O-(E)-feruloylnepitrin (2), 6''-O-(E)-p-coumaroylnepitrin (3), 6-methoxyluteolin 7-glucopyranoside (4), luteolin 3'-O-beta-D-glucuronide (5), luteolin 3'-O-(3''-O-acetyl)-beta-D-glucuronide (6), kaempferol (7), luteolin (8), genkwanin (9), and ladanein (10), together with 1-O-feruloyl-beta-D-glucopyranose (11), 1-O-(4-hydroxybenzoyl)-beta-D-glucopyranose (12), rosmarinic acid (13), carnosic acid (14), and carnosol (15), were isolated from the leaves of Rosmarinus officinalis . The structures were established on the basis of NMR spectroscopic methods supported by HRMS. All isolated compounds were tested for cytotoxicity in human cancer cell lines (HepG2, COLO 205, and HL-60) and for anti-inflammatory activities in lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells. Among them, compounds 14 and 15 were modestly active in the inhibition of nitrite production in macrophages, followed by compounds 8 and 5. Compounds 14 and 15 were more effective as an antiproliferative agent in HL-60 cells with IC(50) values of 1.7 and 5.5 microM, followed by compounds 8 and 7 with IC(50) of 39.6 and 82.0 microM, respectively. In addition, compounds 14 and 15 showed potent antiproliferative effects on COLO 205 cells with IC(50) values of 32.8 and 29.9 microM, respectively.
Flavonoids in Rosmarinus officinalis leaves
Phytochemistry 1994 Nov;37(5):1463-6.PMID:7765765DOI:10.1016/s0031-9422(00)90434-5.
Three new flavonoid glucuronides, luteolin 3'-O-beta-D-glucuronide, luteolin 3'-O-(4"-O-acetyl)-beta-D-glucuronide, and luteolin 3'-O-(3"-O-acetyl)-beta-D-glucuronide, together with hesperidin, were isolated from 50% aqueous MeOH extract of the leaves of rosemary. The structures were established by chemical and spectroscopic methods. Their antioxidant activities were evaluated by a ferric thiocyanate method with hesperidin showing the greatest activity.
Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. postulation of a biosynthetic pathway
J Agric Food Chem 2004 Aug 11;52(16):4987-92.PMID:15291464DOI:10.1021/jf040078p.
The distribution of seven flavonoids, eriocitrin, luteolin 3'-O-beta-D-glucuronide, hesperidin, diosmin, isoscutellarein 7-O-glucoside, hispidulin 7-O-glucoside, and genkwanin, has been studied in Rosmarinus officinalis leaves, flowers, stems, and roots during plant growth. The maximum level reached by luteolin 3'-O-beta-D-glucuronide in leaves during June-August suggests the existence of a delay between the activation of the enzymes involved in the flavanone and flavone biosynthesis. The presence of hesperidin and diosmin in the vascular system is significant, and hesperidin shows even higher levels than the phenolic diterpenes and rosmarinic acid. The distribution of flavonoids observed in R. officinalis suggests a functional and structural relationship between phytoregulators and flavonoids, where flavonoids would be "protectors" of the activity of phytoregulators. A hypothesis for the general pathway of biosynthesis of these compounds in plants of the family Labiatae is proposed.