Meptyldinocap
(Synonyms: 敌螨普,2,4-DNOPC) 目录号 : GC36583
Meptyldinocap (2,4-DNOPC)是一种新型的白粉病（白粉病）杀菌剂。
Cas No.:131-72-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Meptyldinocap (2,4-DNOPC) is a novel powdery mildew (Erysiphe necator) fungicide which shows protectant and post-infective activities.
[1]. Zhang Z, et al. Analytical method for the determination of meptyldinocap as the 2,4-dinitro-octylphenol metabolite in cucumber and soil using LC-MS/MS and a study of the residues in a Chinese cucumber field ecosystem. Pest Manag Sci. 2014 Jan;70(1):97-102
| Cas No. | 131-72-6 | SDF | |
| 别名 | 敌螨普,2,4-DNOPC | ||
| Canonical SMILES | C/C=C/C(OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1C(C)CCCCCC)=O | ||
| 分子式 | C18H24N2O6 | 分子量 | 364.39 |
| 溶解度 | DMSO: ≥ 150 mg/mL (411.65 mM); Ethanol: 100 mg/mL (274.43 mM); Water: < 0.1 mg/mL (insoluble) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.7443 mL | 13.7216 mL | 27.4431 mL |
| 5 mM | 0.5489 mL | 2.7443 mL | 5.4886 mL |
| 10 mM | 0.2744 mL | 1.3722 mL | 2.7443 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Meptyldinocap and azoxystrobin residue behaviors in different ecosystems under open field conditions and distribution on processed cucumber
J Sci Food Agric 2020 Jan 30;100(2):648-655.PMID:31577839DOI:10.1002/jsfa.10059.
Background: Several diseases and insects may cause damage to the normal growth of cucumber. Azoxystrobin and Meptyldinocap, because of their novel mode of action, are effective against pathogens that have developed reduced sensitivity to other fungicides. Azoxystrobin is persistent in various crops and environments. However, there is a lack of research on the dissipation of these two pesticides, especially Meptyldinocap. Results: Analytes could be quantified with decent recoveries of 90-101%, with relative standard deviations (RSDs) of 3.0-10.1%. The terminal residues of Meptyldinocap and azoxystrobin in cucumber were all < limit of quantification (LOQ) (0.02 and 0.05 mg kg-1 ). The half-lives of Meptyldinocap and azoxystrobin were 0.8-1.1 and 1.2-2.8 days, respectively. The processing factors (PFs) for washing were all < 1, but the removal rate for washing was < 29.0%. Peeling had a significant effect on the removal of pesticide. The largest residue reductions were noticed through the pickling process, but special care should be taken regarding residues in the pickling solution as pesticides could transfer to them from cucumber. A more interesting finding was that the degradation of two pesticides was accelerated by the addition of calcium oxide. Conclusion: Pesticide residues on cucumber decreased after these processes. These results enable the health-risks from dietary exposures to pesticide residues to be characterized. They enable maximum residue limits (MRLs) to be established for pesticide residues in food products. They also assist the optimization of food processing with regard to pesticide residue dissipation. © 2019 Society of Chemical Industry.
Analytical method for the determination of Meptyldinocap as the 2,4-dinitro-octylphenol metabolite in cucumber and soil using LC-MS/MS and a study of the residues in a Chinese cucumber field ecosystem
Pest Manag Sci 2014 Jan;70(1):97-102.PMID:23505246DOI:10.1002/ps.3531.
Background: Meptyldinocap (2,4-DNOPC) is a novel powdery mildew (Erysiphe necator) fungicide which shows protectant and post-infective activities. However, there is no reliable validated LC-MS/MS method for measuring trace levels of Meptyldinocap in cucumber. A method for the determination of 2,4-DNOPC using LC-MS/MS in cucumber and soil was developed. Additionally, the mode of degradation and the residue levels in cucumbers and soils were investigated. Results: Recoveries of Meptyldinocap from cucumber and soil samples were found to be 81.4-95.1%. The limits of quantification were found to be 0.01 mg kg(-1) in cucumber and soil. The half-lives of metpyldinocap in cucumbers and soils were in the ranges of 1.6 to 2.2 days and 3.1 to 4.4 days. The harvest residue levels of Meptyldinocap in cucumbers and soils were in the ranges of below 0.01 mg kg(-1) to 0.92 mg kg(-1) , and below 0.01 mg kg(-1) to 0.53 mg kg(-1) . 5 days after application; the harvest residue levels of Meptyldinocap in cucumbers in all treatments were below 0.1 mg kg(-1) . Conclusion: Compared with the MRL for Meptyldinocap in cucumber (0.1 mg kg(-1) ), set by the EU, it is suggested that there should be a pre-harvest interval of 5 days at the recommended rate and times before harvest of cucumber.
Review of the existing maximum residue levels for Meptyldinocap (DE-126) according to Article 12 of Regulation (EC) No 396/2005
EFSA J 2020 Jun 16;18(6):e06157.PMID:32874332DOI:10.2903/j.efsa.2020.6157.
According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance Meptyldinocap (DE-126). To assess the occurrence of Meptyldinocap residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Regulation (EC) No 1107/2009, Commission Regulation (EU) No 188/2011 and the MRLs established by the Codex Alimentarius Commission as well as the European authorisations reported by Member States (including the supporting residues data). Based on the assessment of the available data, MRL proposals were derived and a consumer risk assessment was carried out. Although no apparent risk to consumers was identified, some information required by the regulatory framework was missing. Hence, the consumer risk assessment is considered indicative only and some MRL proposals derived by EFSA still requires further consideration by risk managers.
[Determination of Meptyldinocap residues in vegetable and fruit by liquid chromatography-tandem mass spectrometry]
Se Pu 2012 Sep;30(9):962-5.PMID:23285981DOI:10.3724/sp.j.1123.2012.06008.
A method was developed for the determination of the residues of Meptyldinocap (2,4-dinitro-6-(1-methylheptyl) phenyl crotonate, 2,4-DNOPC) as 2, 4-dinitrooctylphenol (2,4-dinitro-6-(1-methylheptyl) phenol, 2,4-DNOP), which is a hydrolysate of 2,4-DNOPC, in six vegetable and fruit by using liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). The residues of 2,4-DNOPC in vegetable and fruit samples were extracted by the mixture of acetone, methanol and hydrochloric acid, then extracted by liquid-liquid partitioning, hydrolyzed under alkaline condition with ultrasonication, and extracted again by liquid-liquid partitioning, then analyzed by using LC-MS/MS in multiple reaction monitoring (MRM) mode via negative electrospray ionization with an Agilent ZORBAX SB-C, column. The method was validated at four fortification levels in vegetable and fruit. The validation results were as follows: the recoveries of 2,4-DNOPC in cabbages were from 89.7% to 93.3% (the relative standard deviations (RSD) of 6. 3% - 8.5%), in cucumbers from 87.7% to 95.1% (RSD of 5.8% -10.4%), in tomatoes from 89.3% to 96.0% (RSD of 6.8% -9.2%), in apples from 92.0% to 98.3% (RSD of 5.1% - 10.3%), in pears from 89.0% to 95.0% (RSD of 5.3% -10.2%), in grapes from 81.2% to 95.8% (RSD of 5.8% - 10.4%). The limits of quantification of 2,4-DNOPC in all the test samples were 0. 01 mg/kg. The results showed that the method is simple, rapid, and is characterized with acceptable sensitivity and accuracy to meet the requirements of the pesticide residue analysis. This method is applicable to confirm the residues of Meptyldinocap in vegetable and fruit samples.
Analytical method validation for the determination of Meptyldinocap as 2,4-dinitrooctylphenol metabolite in mango and soil using LC-MS/MS and dissipation study of the fungicide in Indian mango field ecosystem
J Agric Food Chem 2010 Aug 25;58(16):8911-7.PMID:23654228DOI:10.1021/jf1008346.
An analytical method for the quantitative determination of Meptyldinocap (2,4-DNOPC) as 2,4-dinitrooctylphenyl (2,4-DNOP) in mango and soil was developed as well as validated using liquid chromatography tandem mass spectrometry (LC-MS/MS). The method comprised an extraction with an acetone:methanol:4 N HCl (100:10:5, v/v/v) mixture followed by hydrolytic conversion of parent 2,4-DNOPC to the corresponding phenol metabolite (2,4-DNOP), and cleanup was done by liquid:liquid partition using ethyl acetate. Final quantitation was performed by LC-MS/MS of 2,4-DNOP with negative electrospray ionization using gradient elution. The method was validated at concentrations ranging from 0.025 to 2 μg/g, and the limit of quantification (LOQ) of Meptyldinocap in mango and soil samples was 0.025 μg/g. The recovery of Meptyldinocap from mango and soil sample was found to be 93-98% spiked at different levels with analyte, and the relative standard deviation for repeatability (RSD(r)) and reproducibility (RSD(R)) were acceptable (2-6%). The method was rugged as evident from a low measurement uncertainty at 0.05 μg/g. In order to evaluate its safety use in India a multilocational field dissipation study on Meptyldinocap in mango was conducted by following the proposed analytical method.