Nalfurafine hydrochloride
(Synonyms: 盐酸纳呋拉啡; TRK-820 hydrochloride) 目录号 : GC36689
An Analytical Reference Standard
Cas No.:152658-17-8
Sample solution is provided at 25 µL, 10mM.
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Nalfurafine (hydrochloride) is an analytical reference standard categorized as an opioid.1 Naflurafine decreases ethanol consumption in male mice and increases ethanol consumption in female mice.2 It is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.
1.Watanabe, Y., Kitazawa, S., Fujii, H., et al.Design, synthesis, and structure-activity relationship of novel opioid κ receptor selective agonists: α-Iminoamide derivatives with an azabicyclo[2.2.2]octene skeletonBioorg. Med. Chem. Lett.24(21)4980-4983(2014) 2.French, A.R., Gutridge, A.M., Yuan, J., et al.Sex- and β-arrestin-dependent effects of kappa opioid receptor-mediated ethanol consumptionPharmacol. Biochem. Behav.216173377(2022)
Animal experiment: | Rats: Nalfurafine is given to male Sprague-Dawley rats at volume of 1 mL/kg. After collecting control samples for 80 min, PCP (10 mg/kg, i.p.) is administered to the rats, and then the collection of dialysate is continued for 180 min. Pre-treatment with TRK-820 or vehicle is performed subcutaneously 5 min before the administration of PCP. Dopamine and serotonin levels in the dialysate are quantified by high-performance liquid chromatography[2]. Mice: Chronic dry skin on the nape of the neck is induced on the C57BL/6 mice. Nalfurafine (20 μg/kg) or saline is administered. Then alloknesis testing is conducted[1]. |
References: [1]. Akiyama T, et al. Nalfurafine suppresses pruritogen- and touch-evoked scratching behavior in models of acute and chronic itch in mice. Acta Derm Venereol. 2015 Feb;95(2):147-50. | |
| Cas No. | 152658-17-8 | SDF | |
| 别名 | 盐酸纳呋拉啡; TRK-820 hydrochloride | ||
| Canonical SMILES | O[C@@]1(CC[C@@H](N(C)C(/C=C/C2=COC=C2)=O)[C@]3([H])OC4=C5O)[C@]63C4=C(C=C5)C[C@@]1([H])N(CC7CC7)CC6.[H]Cl | ||
| 分子式 | C28H33ClN2O5 | 分子量 | 513.03 |
| 溶解度 | DMSO: 33.33 mg/mL (64.97 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.9492 mL | 9.746 mL | 19.492 mL |
| 5 mM | 0.3898 mL | 1.9492 mL | 3.8984 mL |
| 10 mM | 0.1949 mL | 0.9746 mL | 1.9492 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet