Neoandrographolide

Neoandrographolide is one of the principle diterpenoids isolated from A. paniculata, a well-recognized medicinal plant in Asia. Extracts from A. paniculata have been reported to exert a wide range of therapeutic actions, including immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, anti-viral, anti-bacterial, anti-diabetic, anti-oxidative stress, antipyretic, anti-edematogenic, and anti-nociceptive activities.¹ Neoandrographolide has been shown to inhibit LPS-induced nitric oxide production in inflammatory macrophages after oral administration to mice (25 mg/kg) or by direct addition to cultured macrophages (IC₅₀ = 35.5 ?M).² At 25 ?M, it can reduce VEGF-induced proliferation of human umbilical vein endothelial cells.³ Neoandrographolide also inhibits the pro-protein convertase furin with an IC₅₀ value of 53.5 ?M.⁴

1.Jarukamjorn, K., and Nemoto, N.Pharmacological aspects of Andrographis paniculata on health and its major diterpenoid constituent andrographolideJ. Health Sci.54(4)370-381(2008) 2.Batkhuu, J., Hattori, K., Takano, F., et al.Suppression of NO production in activated macrophages in vitro and ex vivo by neoandrographolide isolated from Andrographis paniculataBiol. Pharm. Bull.25(9)1169-1174(2002) 3.Gong, C., Xu, C., Ji, L., et al.A novel semi-synthetic andrographolide analogue A5 inhibits tumor angiogenesis via blocking the VEGFR2-p38/ERK1/2 signal pathwayBiosci. Trends7(5)230-236(2013) 4.Basak, A., Cooper, S., Roberge, A.G., et al.Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl estersBiochem. J.338(Pt 1)107-113(1999)