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Norepinephrine hydrochloride Sale

(Synonyms: 去甲肾上腺素盐酸盐; Levarterenol hydrochloride; L-Noradrenaline hydrochloride) 目录号 : GC36758

A racemic mixture of of L-norepinephrine and D-norepinephrine

Norepinephrine hydrochloride Chemical Structure

Cas No.:329-56-6

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Sample solution is provided at 25 µL, 10mM.

Description

(±)-Norepinephrine is a racemic mixture of the endogenous neurotransmitter (–)-norepinephrine and (+)-norepinephrine. It induces cAMP accumulation in rat cerebral cortical membranes when used at concentrations ranging from 1 to 100 ?M.1 (±)-Norepinephrine induces contraction of bovine anterior cerebral, middle cerebral, and internal carotid arterial strips (EC50s = 0.91, 0.92, and 0.87 ?M, respectively) but induces relaxation of bovine posterior cerebral arterial strips (EC50 = 0.95 ?M).2

1.Tadokoro, C., Kiuchi, Y., Yamazaki, Y., et al.Behavioral stimulation without alteration of β and 5-HT receptors and adenylate cyclase activity in rat brain after chronic sertraline administrationPsychopharmacology (Berl.)130(2)124-130(1997) 2.Ayajiki, K., and Toda, N.Isolated bovine cerebral arteries from rostral and caudal regions: Distinct responses to adrenoceptor agonistsEur. J. Pharmacol.191(3)417-425(1990)

实验参考方法

Cell experiment:

Subcutaneous preadipocytes derived from a 38-year old non-diabetic female donor are immortalized with TERT and HPV E6/E7. For the current studies, a stable diploid clone (referred to as clone B) with consistent differentiation capacity is isolated by ring cloning. Cells are grown in preadipocyte PGM2 media. Once cells are confluent, differentiation is induced by incubation in differentiation media consisting of dexamethasone, IBMX, indomethacin, and additional insulin. Cells are differentiated for 10 days. Prior to treatment, media is replaced with PGM2 media for one day and then switched to serum-free media overnight for treatments. Adipocytes are treated for 6 hours with vehicle, Norepinephrine (NE, 10 μM), CGP (10 nM), or Norepinephrine (NE) and CGP[2].

References:

[1]. MacGregor DA, et al. Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes. Chest. 1996 Jan;109(1):194-200.
[2]. Littlejohn NK, et al. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep. 2016 Aug 9;16(6):1548-60.

化学性质

Cas No. 329-56-6 SDF
别名 去甲肾上腺素盐酸盐; Levarterenol hydrochloride; L-Noradrenaline hydrochloride
Canonical SMILES OC1=CC=C([C@@H](O)CN)C=C1O.Cl
分子式 C8H12ClNO3 分子量 205.64
溶解度 5 mg/mL in DMSO (ultrasonic and warming and heat to 40°C) 储存条件 Store at -20°C,protect from light
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.8629 mL 24.3143 mL 48.6287 mL
5 mM 0.9726 mL 4.8629 mL 9.7257 mL
10 mM 0.4863 mL 2.4314 mL 4.8629 mL
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