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Palonosetron Sale

(Synonyms: 帕洛诺司琼) 目录号 : GC36844

Palonosetron (RS25259, RS 25259 197) is a 5-HT3 antagonist with Ki value of 0.17 nM. It is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).

Palonosetron Chemical Structure

Cas No.:135729-61-2

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Sample solution is provided at 25 µL, 10mM.

Description

Palonosetron (RS25259, RS 25259 197) is a 5-HT3 antagonist with Ki value of 0.17 nM. It is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).

Palonosetron is a 5-HT3 receptor antagonist with a high binding affinity for this receptor and little or no affinity for other receptors[1].

Palonosetron has a longer half-life and a higher binding affinity than the first-generation 5-HT3 receptor antagonists. After intravenous dosing of palonosetron in healthy subjects and cancer patients, an initial decline in plasma concentration is followed by a slow elimination from the body. Mean maximum plasma concentration and area under the concentration-time curves are generally dose-proportional over the dose range of 0.3 to 90 μg/kg in healthy subjects and in cancer patients. Palonosetron has a volume of distribution of approximately 8.3 ± 2.5 L/kg and is 62% bound to plasma proteins. It is eliminated from the body through renal excretion and metabolic pathways. The mean terminal elimination half-life is approximately 40 hours[1].

[1] Rudolph M Navari. Cancer Manag Res. 2009, 1: 167-176. [2] Price KL, et al. ACS Chem Neurosci. 2016, 7(12):1641-1646.

化学性质

Cas No. 135729-61-2 SDF
别名 帕洛诺司琼
Canonical SMILES O=C1N(C[C@@]([H])(CCC2)C3=C2C=CC=C13)[C@@H]4CN5CCC4CC5
分子式 C19H24N2O 分子量 296.41
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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1 mM 3.3737 mL 16.8685 mL 33.7371 mL
5 mM 0.6747 mL 3.3737 mL 6.7474 mL
10 mM 0.3374 mL 1.6869 mL 3.3737 mL
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