Phenoxodiol

Idronoxil is a phenol and derivative of genistein that has been found in B. tournefortii and has anticancer activity.^1,2,3 It reduces the viability of R182S, R127, Hey, CP70, A2780, R187, R188, and R207 primary ovarian cancer cells, but not non-cancerous ovarian surface epithelial (OSE) cells, when used at a concentration of 10 ?g/ml.² Idronoxil (1 ?g/ml) reduces colony formation and induces apoptosis in R127 and CP70 primary ovarian cancer cells, respectively, and restores sensitivity to Fas-mediated apoptosis in CP70 cells. In vivo, idronoxil (50 and 75 mg/kg) increases latency to tumor formation and reduces tumor multiplicity in a rat model of mammary carcinogenesis induced by dimethylbenz[a]anthracene (DMBA).³

1.Rahmani, R., Bouajila, J., Jouaidi, M., et al.African mustard (Brassica tournefortii) as source of nutrients and nutraceuticals propertiesJ. Food Sci.85(6)1856-1871(2020) 2.Kamsteeg, M., Rutherford, T., Sapi, E., et al.Phenoxodiol – an isoflavone analog – induces apoptosis in chemoresistant ovarian cancer cellsOncogene22(17)2611-2620(2003) 3.Constantinou, A.I., Mehta, R., and Husband, A.Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague–Dawley ratsEur. J. Cancer39(7)1012-1018(2004)