Picaridin
(Synonyms: 埃卡瑞丁,Lcaridin) 目录号 : GC36913
An insect repellent
Cas No.:119515-38-7
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Picaridin is an insect repellent.1,2,3 It inhibits A. aegypti odorant receptor 2 (AaOR2) or AaOR8 in the presence of their odorant activators, indole and octenol, respectively, expressed in Xenopus oocytes (IC50s = 1,452 and 1,911 ?M, respectively).1 Picaridin reduces the number of entries into a food chamber by female D. melanogaster in an olfactory-based choice assay.2 It acts synergistically with the non-pyrethroid insecticide pyrimiphos methyl to increase mortality of A. gambiae and reduce blood feeding when used at a concentration of 10 g/m2 on nets surrounding guinea pig cages.3 Formulations containing picaridin have been used as insect repellents against flies, mosquitoes, chiggers, ticks, and fleas.
1.Bohbot, J.D., and Dickens, J.C.Insect repellents: Modulators of mosquito odorant receptor activityPLoS One5(8)1-11(2010) 2.Syed, Z., Pelletier, J., Flounders, E., et al.Generic insect repellent detector from the fruit fly Drosophila melanogasterPLoS One6(3)e17705(2011) 3.Pennetier, C., Corbel, V., Boko, P., et al.Synergy between repellents and non-pyrethroid insecticides strongly extends the efficacy of treated nets against Anopheles gambiaeMalar. J.638(2007)
| Cas No. | 119515-38-7 | SDF | |
| 别名 | 埃卡瑞丁,Lcaridin | ||
| Canonical SMILES | O=C(N1C(CCCC1)CCO)OC(CC)C | ||
| 分子式 | C12H23NO3 | 分子量 | 229.32 |
| 溶解度 | DMSO: 250 mg/mL (1090.18 mM) | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.3607 mL | 21.8036 mL | 43.6072 mL |
| 5 mM | 0.8721 mL | 4.3607 mL | 8.7214 mL |
| 10 mM | 0.4361 mL | 2.1804 mL | 4.3607 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Picaridin: a new insect repellent
J Drugs Dermatol 2004 Jan-Feb;3(1):59-60.PMID:14964747doi
Picaridin is a new insect repellent that is comparable in effect and less irritating than diethyl toluamide (deet). Its activity and effects are reviewed in this article.
Arthropod bites
Am Fam Physician 2013 Dec 15;88(12):841-7.PMID:24364549doi
The phylum Arthropoda includes arachnids and insects. Although their bites typically cause only local reactions, some species are venomous or transmit disease. The two medically important spiders in the United States are widow spiders (Latrodectus), the bite of which causes intense muscle spasms, and the brown recluse (Loxosceles), which may cause skin necrosis. Widow bites usually respond to narcotics, benzodiazepines, or, when necessary, antivenom. Most recluse bites resolve uneventfully without aggressive therapy and require only wound care and minor debridement. Tick bites can transmit diseases only after prolonged attachment to the host. Treatment of clothing with permethrin and proper tick removal greatly reduce the risk of infection. Ticks of medical importance in the United States include the black-legged tick, the Lone Star tick, and the American dog tick. The prophylactic use of a single dose of doxycycline for Lyme disease may be justified in high-risk areas of the country when an attached, engorged black-legged tick is removed. Bites from fleas, bedbugs, biting flies, and mosquitoes present as nonspecific pruritic pink papules, but the history and location of the bite can assist with diagnosis. Flea bites are usually on ankles, whereas mosquito bites are on exposed skin, and chigger bites tend to be along the sock and belt lines. Antihistamines are usually the only treatment required for insect bites; however, severe mosquito reactions (skeeter syndrome) may require prednisone. Applying insect repellent containing diethyltoluamide (DEET) 10% to 35% or Picaridin 20% is the best method for preventing bites.
The toxicity of Picaridin containing insect repellent reported to the National Poison Data System
Clin Toxicol (Phila) 2016 Sep;54(8):655-8.PMID:27213820DOI:10.1080/15563650.2016.1186806.
Context: While low toxicity is reported, there are sparse data on the safety of acute Picaridin (icaridin) exposures in humans. Objective: The purpose of this study was to review National Poison Data System (NPDS) data regarding ingestion of insect repellents containing Picaridin and compare those to insect repellents containing DEET and other insect repellents not containing DEET. Methods: NPDS was queried for single agent human insect repellent ingestions reported between 1 January 2000 and 31 May 2015 using the American Association of Poison Control Center generic categories 201048 (Insect Repellents with DEET) and 201049 (Insect Repellents without DEET). Picaridin-containing product exposures were assessed using Poisindex(®) product ID 6744589. Insect repellents of unknown type were not included. Results: 68,429 exposures occurred; 24% were non-DEET-containing products, of which 2% were picaridin-containing products. Among Picaridin exposures, 92.9% were managed outside of a health-care facility; there were no reported cases of major effect or death, and only one case of moderate effect. Primary symptoms across all insect repellent exposures included ocular irritation/pain, vomiting, red eye/conjunctivitis, and oral irritation. Treatment primarily included dilution/irrigation/wash. Conclusion: Unintentional ingestion of picaridin-containing and other insect repellents was associated only with minor toxicity and was generally managed outside of a health-care facility.
Mosquito repellents for the traveller: does Picaridin provide longer protection than DEET?
J Travel Med 2018 May 1;25(suppl_1):S10-S15.PMID:29718433DOI:10.1093/jtm/tay005.
Background: This review examines the published laboratory and field tests where the repellents DEET and Picaridin have been compared for their efficacy as repellents against mosquitoes. The review is limited to an assessment of whether the duration of protection afforded by Picaridin is similar to or better than DEET. Method: Identification and analysis of laboratory and field-based trials published in peer-reviewed journals that compared DEET to Picaridin efficacy. Results: Only eight field studies and three laboratory studies met the review criteria for inclusion and most were considered to be of high risk of bias and of lower quality when judged against evidence-based principles. Overall, the studies showed little potential difference between DEET and Picaridin applied at the same dosage, with some evidence pointing to a superior persistence for Picaridin. Conclusion: Applied dosage is one important variable in determining the persistence of a repellent experienced by users but the maximum concentration in current Picaridin formulation is <30%w/v. Therefore, where only 30% DEET or lower concentrations are available, then on current evidence, it is reasonable to offer DEET or Picaridin as a first choice. Where >50% DEET products are available then the protection time advantage associated with these formulations reasonably can be invoked to consider them as first choice repellents.
Determination of antimicrobial properties of Picaridin and DEET against a broad range of microorganisms
World J Microbiol Biotechnol 2014 Feb;30(2):407-11.PMID:23933806DOI:10.1007/s11274-013-1456-4.
Insect repellents are topically applied to the skin and clothing of human and pet to keep flies, mosquitoes, and ticks away. Two important repellents, N,N-diethyl-meta-toluamide (DEET) and Picaridin, have been widely used since their discovery. Although repellency and toxicological effects of DEET and Picaridin on human being and insects are well documented without understanding molecular mechanisms, there have been no attempts to study their effects on microorganisms up to now. In the current study, DEET and Picaridin have been investigated for their antimicrobial characteristics against a broad range of microorganisms including bacteria, yeast, and fungi for the first time. They exhibited considerable antibacterial, anticandidal and antifungal properties. Even though bacteria was found to be more sensitive to Picaridin, yeast and fungi were more susceptible to DEET. Antimicrobial properties of these two repellents will increase the usage and application areas of the products containing DEET and Picaridin.