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Picfeltarraenin IV Sale

(Synonyms: 苦玄参苷 IV) 目录号 : GC36916

Picfeltarraenin IV 是一种三萜类化合物,可从 Picriafel-terrae Lour (P.fel-terrae) 中提取。Picfeltarraenin IV 是一种乙酰胆碱酯酶 (AChE) 抑制剂。Picfeltarraenin IV 可用于治疗感染,癌症和炎症。

Picfeltarraenin IV Chemical Structure

Cas No.:184288-35-5

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1mg
¥2,574.00
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5mg
¥7,713.00
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产品描述

Picfeltarraenin IV, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IV can be used for the treatment of herpes infections, cancer and inflammation[1]. AChE[1]

[1]. Wen L, et al. Bioassay- and liquid chromatography/mass spectrometry-guided acetylcholinesterase inhibitors from Picriafel-terrae. Pharmacogn Mag. 2013 Oct;9(Suppl 1):S25-31.

Chemical Properties

Cas No. 184288-35-5 SDF
别名 苦玄参苷 IV
分子式 C47H72O18 分子量 925.06
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 1.081 mL 5.4051 mL 10.8101 mL
5 mM 0.2162 mL 1.081 mL 2.162 mL
10 mM 0.1081 mL 0.5405 mL 1.081 mL
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Research Update

Bioassay- and liquid chromatography/mass spectrometry-guided acetylcholinesterase inhibitors from Picriafel-terrae

Pharmacogn Mag 2013 Oct;9(Suppl 1):S25-31.PMID:24143041DOI:10.4103/0973-1296.117857.

Background: Picria fel-terrae is a traditional Chinese medicine. Materials and methods: A new approach to the search for acetylcholinesterase (AChE) inhibitors from Picria fel-terrae is presented. Results: Bioassay- and LC-MS-guided fractionation of the ethyl acetate extract was from traditional Chinese medicine P.fel-terrae. Following primary extraction, the ethyl acetate extracts fraction of P.fel-terrae showed strong AChE inhibitory activities. So the sample was separated using highperformance liquid chromatography (HPLC). The effluent was split towards two identical 96-well fraction collectors, and the presence of the biologically interesting portion and chromatographic fractions could be readily detected by analyzing selected ion chromatograms through an electrophoresis-electrospray ionization mass spectrometry (ESIMS) system for accurate mass measurement. One 96-well plate was used for a bioassay (AChE-inhibitory assay) and detected the bioactivity and position of the relevant peak in the chromatogram. The positive well in the second 96-well plate was used for identification by LC-(+) ESIMS. Conclusion: As abovementioned, the AChE inhibitory constituents from P.fel-terrae by LC-bioassay-ESIMS were rapid identified. Liquid chromatography/ mass spectrometry (LC-MS) screening detected the presence of six active compounds, identified as picfeltarraenin IA (1), picfeltarraenin IB (2), Picfeltarraenin IV (3), picfeltarraenin X (4), picfeltarraenin XI (5), and one unknown compound. The structures were further determined by 13C NMR. The six compounds expressed stronger AChE inhibition than the known AChE inhibitorTacrine. Above all, the value of this LC-bioassay-ESIMS methodology is highlighted by the finding and structure elucidation of the active constituents from many other structural families of natural products.

Complement-inhibiting cucurbitacin glycosides from Picria fel-terrae

J Nat Prod 1998 Jun 26;61(6):757-61.PMID:9644059DOI:10.1021/np9705773.

Four cucurbitacin glycosides were isolated from Picriafel-terrae and identified by MS and NMR spectroscopy as picfeltarraenin IA (1), picfeltarraenin IB (2), Picfeltarraenin IV (4), and a new compound picfeltarraenin VI (3) (picfeltarraegenin I 3-O-beta-D-xylopyranoside). All four compounds acted as inhibitors on both the classical and alternative pathways of the complement system, with compound 3 exhibiting the highest inhibitory activity (IC50 29 +/- 2 microM and 21 +/- 1 microM, respectively). Compounds 1-4 showed no antiviral, antibacterial, or antifungal activities. Picfeltarraenin IA and IB were tested in an in vitro human tumor cell line panel, but displayed no cytotoxic activity.

A new cucurbitacin from Picria fel-terrae

J Asian Nat Prod Res 2006 Jun;8(4):367-71.PMID:16864449DOI:10.1080/10286020500034998.

A new cucurbitacin, picfeltarraenone II (1) as well as four known cucurbitacins, picfeltarraegenin I (2), picfeltarraenin IA (3), picfeltarraenin IB (4), and Picfeltarraenin IV (5), have been isolated and characterized from the whole plant of Picria fel-terrae. The purity of picfeltarraenin IA has been determined by TLC and HPLC.