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Polygalic acid Sale

(Synonyms: 远志皂甙) 目录号 : GC36946

Polygalic acid (Senegenic acid), a triterpenoid saponin, shows expectorant, emetic and stimulant effects.

Polygalic acid Chemical Structure

Cas No.:1260-04-4

规格 价格 库存 购买数量
5mg
¥300.00
现货
10mg
¥500.00
现货
20mg
¥900.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Polygalic acid (Senegenic acid), a triterpenoid saponin, shows expectorant, emetic and stimulant effects.

Chemical Properties

Cas No. 1260-04-4 SDF
别名 远志皂甙
Canonical SMILES C[C@@]1(C(O)=O)[C@@H](O)[C@@H](O)C[C@]2(C)[C@@]3([H])CCC4=C(CC[C@@]5(CCC(C)(C[C@]54[H])C)C(O)=O)[C@@](C)3CC[C@@]12[H]
分子式 C29H44O6 分子量 488.66
溶解度 DMSO: ≥ 250 mg/mL (511.60 mM) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 2.0464 mL 10.2321 mL 20.4641 mL
5 mM 0.4093 mL 2.0464 mL 4.0928 mL
10 mM 0.2046 mL 1.0232 mL 2.0464 mL
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Research Update

In vivo metabolism study of Polygalic acid in rat using HPLC-ESI-MSn

Biomed Chromatogr 2012 Feb;26(2):220-4.PMID:21618563DOI:10.1002/bmc.1650

A very simple and direct method has been established for the determination of Polygalic acid and its metabolites in rat urine based on HPLC coupled with electrospray ionization multi-stage tandem mass spectrometry (HPLC-ESI-MS(n)). The rats were administered a single dose (100 mg/kg) of Polygalic acid by oral gavage. The urine samples were collected and purified through a C(18) solid-phase extraction cartridge, and then these pretreated samples were injected into a reversed-phase C(18) column with a gradient elution program, whereas acetonitrile-0.5% aqueous formic acid was used as mobile phase and detected by an on-line MS/MS system. As a result, the parent drug and its four metabolites were identified and characterized in rat urine for the first time by comparing their changes in molecular mass (ΔM), retention times and full-scan MS(n) spectra with those of the parent drug. A possible metabolic pathway of Polygalic acid was investigated and proposed. More importantly, the results demonstrated that the newly developed method (HPLC-ESI-MS(n)) was sensitive, simple and suitable for the determination of Polygalic acid and its metabolites in biological samples.