Quillaic acid
(Synonyms: 皂树皮提取物,Quillaja sapogenin) 目录号 : GC37060
A triterpene saponin with diverse biological activities
Cas No.:631-01-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Quillaic acid is a triterpene saponin that has been found in Q. saponaria bark and has diverse biological activities.1,2,3 It is cytotoxic to SNU-1 and KATO III gastric cancer cells (IC50s = 13.6 and 67 ?M, respectively).1 Quillaic acid induces hot plate analgesia in mice (ED50 = 20.7 mg/kg).2 It reduces ear edema induced by arachidonic acid or phorbol 12-myristate 13-acetate in mice when administered topically at doses of 0.7 and 1.6 mg/ear, respectively.3
1.Guzmán, L., Villalón, K., Marchant, M.J., et al.In vitro evaluation and molecular docking of QS-21 and quillaic acid from Quillaja saponaria Molina as gastric cancer agentsSci. Rep.10(1)10534(2020) 2.Arrau, S., Delporte, C., Cartagena, C., et al.Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in miceJ. Ethnaopharmacol.133(1)164-167(2011) 3.Rodríguez-Díaz, M., Delporte, C., Cartagena, C., et al.Topical anti-inflammatory activity of quillaic acid from Quillaja saponaria Mol. and some derivativesJ. Pharm. Pharmacol.63(5)718-724(2011)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.0547 mL | 10.2737 mL | 20.5474 mL |
| 5 mM | 0.4109 mL | 2.0547 mL | 4.1095 mL |
| 10 mM | 0.2055 mL | 1.0274 mL | 2.0547 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。