Racanisodamine
(Synonyms: 消旋山莨菪碱) 目录号 : GC37064
A natural α1-adrenoceptor antagonist
Cas No.:17659-49-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Racanisodamine is a natural tropane alkaloid shown to be a weak antagonist of α1-adrenoceptors, blocking WB-4101 and clonidine binding in brain membrane preparations with pKi values of 2.63 and 1.61, respectively.1 Racanisodamine also has antioxidant effects that may protect against free radical-induced cellular damage.2 Racanisodamine is predominantly found in the roots of A. tanguticus, which is used in traditional Chinese medicine for topical applications.3
1.Varma, D.R., and Yue, T.L.Adrenoceptor blocking properties of atropine-like agents anisodamine and anisodine on brain and cardiovascular tissues of ratsBr. J. Pharmacol.87(3)587-594(1986) 2.Poupko, J.M., Baskin, S.I., and Moore, E.The pharmacological properties of anisodamineJ. Appl. Toxicol.27(2)116-121(2007) 3.Ma, L., Gu, R., Tang, L., et al.Important poisonous plants in Tibetan ethnomedicineToxins (Basel)7(1)138-155(2015)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.2747 mL | 16.3736 mL | 32.7472 mL |
| 5 mM | 0.6549 mL | 3.2747 mL | 6.5494 mL |
| 10 mM | 0.3275 mL | 1.6374 mL | 3.2747 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。