SB-269970
(Synonyms: SB269970) 目录号 : GC37599
A 5-HT7A and adrenergic α2 receptor antagonist
Cas No.:201038-74-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
The transduction of neurobehavioral effects by serotonin (5-hydroxy tryptamine; 5-HT) is mediated by at least seven major 5-HT receptor subtypes. SB-269970 is a potent 5-HT7A antagonist (pKi = 8.9) that demonstrates >50-fold binding selectivity over 5-HT5A and >250-fold selectivity over 5-HT1, 5-HT2, 5-HT4, 5-HT6, adrenergic α1, dopamine D2, and dopamine D3 receptors.1 It is also reported to block adrenergic α2 receptors in guinea pig vas deferens.2 SB-269970 has been used to target the 5-HT7 receptor in the study of schizophrenia-like cognitive deficits.3
1.Lovell, P.J., Bromidge, S.M., Dabbs, S., et al.A novel, potent, and selective 5-HT7 antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phenol (SB-269970)J. Med. Chem.43(3)342-345(2000) 2.Foong, J.P.P., and Bornstein, J.C.5-HT antagonists NAN-190 and SB 269970 block α2-adrenoceptors in the guinea pigNeuroreport20(3)325-330(2009) 3.Nikiforuk, A., Kos, T., Fijal, K., et al.Effects of the selective 5-HT7 receptor antagonist SB-269970 and amisulpride on ketamine-induced schizophrenia-like deficits in ratsPLoS One8(6)1-12(2013)
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.837 mL | 14.1848 mL | 28.3696 mL |
| 5 mM | 0.5674 mL | 2.837 mL | 5.6739 mL |
| 10 mM | 0.2837 mL | 1.4185 mL | 2.837 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
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