Scyllo-Inositol
(Synonyms: 鲨肌醇) 目录号 : GC37610
A stereoisomer of inositol
Cas No.:488-59-5
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
scyllo-Inositol is a stereoisomer of inositol. It induces a structural transition in amyloid-β (1-42) (Aβ42), but not Aβ40, from a random coil to β-sheet structure but prevents Aβ42 fibril formation in cell-free assays.1 scyllo-Inositol reduces Aβ40- and Aβ42-induced decreases in the survival of PC12 cells. It reduces increases in soluble and insoluble brain Aβ40 and Aβ42 levels in four- and six-month-old mice in the TgCRND8 model of Alzheimer’s disease when administered starting at six weeks of age, which is prior to the onset of increased Aβ levels and spatial learning deficits.2 It also reduces increases in insoluble brain Aβ40 and Aβ42 levels in six-month-old mice when administered starting at five months of age when the neuropathological and learning deficits are already established. scyllo-Inositol improves established spatial learning and memory deficits in the Morris water maze when compared with TgCRND8 control and non-transgenic littermate control mice. It also improves survival of TgCRND8 mice.
1.McLaurin, J., Golomb, R., Jurewicz, A., et al.Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid β peptide and inhibit Αβ-induced toxicityJ. Biol. Chem.275(24)18495-18502(2000) 2.McLaurin, J., Kierstead, M.E., Brown, M.E., et al.Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse modelNat. Med.12(7)801-808(2006)
制备储备液 | |||
![]() |
1 mg | 5 mg | 10 mg |
1 mM | 5.5506 mL | 27.7531 mL | 55.5062 mL |
5 mM | 1.1101 mL | 5.5506 mL | 11.1012 mL |
10 mM | 0.5551 mL | 2.7753 mL | 5.5506 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。