Secoisolariciresinol
(Synonyms: (+)-开环异落叶松脂素) 目录号 : GC37616
A lignan with diverse biological activities
Cas No.:29388-59-8
Sample solution is provided at 25 µL, 10mM.
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(–)-Secoisolariciresinol is a lignan that has been found in flaxseed and has diverse biological activities.1,2,3 It scavenges DPPH radicals (IC50 = 13.7 ?g/ml in a cell-free assay).1 (–)-Secoisolariciresinol (0.1-100 ?M) stimulates IgM production in HB4C5 hybridoma cells.2 It induces estrogen receptor-dependent gene expression in a reporter assay, as well as stimulates proliferation of MCF-7 human breast cancer cells, in a concentration-dependent manner. (–)-Secoisolariciresinol (5.8 mg/kg, p.o.) reduces weight gain and serum adiponectin levels in a mouse model of obesity induced by a high-fat diet (HFD).3
1.Rao, J.M., Tiwari, A.K., Kumar, U.S., et al.(-)-Secoisolariciresinol as an antioxidant obtained from a new natural source namely Stereopermum personatum(2002) 2.Sugahara, T., Yamauchi, S., Nishimoto, S., et al.The structure-activity relationships of flaxseed lignan, secoisolariciresinolInterdisciplinary Studies on Environmental Chemistry263-268(2008) 3.Tominaga, S., Nishi, K., Nishimoto, S., et al.(–)-Secoisolariciresinol attenuates high-fat diet-induced obesity in C57BL/6 miceFood Funct.3(1)76-82(2012)
| Cas No. | 29388-59-8 | SDF | |
| 别名 | (+)-开环异落叶松脂素 | ||
| Canonical SMILES | COC1=C(O)C=CC(C[C@@H](CO)[C@H](CO)CC2=CC(OC)=C(O)C=C2)=C1 | ||
| 分子式 | C20H26O6 | 分子量 | 362.42 |
| 溶解度 | DMSO: 10 mM | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.7592 mL | 13.7961 mL | 27.5923 mL |
| 5 mM | 0.5518 mL | 2.7592 mL | 5.5185 mL |
| 10 mM | 0.2759 mL | 1.3796 mL | 2.7592 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet