Home>>Signaling Pathways>> Tyrosine Kinase>> FGFR>>SSR128129E free acid

SSR128129E free acid Sale

(Synonyms: SSR free acid) 目录号 : GC37679

An FGFR inhibitor

SSR128129E free acid Chemical Structure

Cas No.:848463-13-8

规格 价格 库存 购买数量
10mg
¥1,035.00
现货
50mg
¥3,150.00
现货

电话:400-920-5774 Email: sales@glpbio.cn

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

Description

SSR 128129E is a potent inhibitor of the FGF receptor (FGFR; IC50 = 1.9 nM).1 It reduces FGF2-induced endothelial cell proliferation and migration (IC50s = 31 and 15.2 nM, respectively), as well as lamellipodia formation in vitro. SSR 128129E also reduces proliferation of PAE cells expressing FGFR1, mPanc02 cells expressing FGFR2, hB9 myeloma cells expressing FGFR3, and HUVECs expressing FGFR4 when used at a concentration of 100 nM. In vivo, SSR 128129E (30 mg/kg per day) reduces limb swelling, redness, and deformity and improves performance in an exercise endurance test in a mouse model of arthritis. It reduces tumor growth and metastasis and enhances antitumor activity of the VEGF receptor (VEGFR) antibody αVEGFR2 in a Panc02 mouse orthotopic tumor model. SSR 128129E (50 mg/kg per day) reduces atherosclerotic lesion size in the aortic sinus of apoE-/- mice.2 It also reduces intimal hyperplasia following jugular vein-to-artery bypass grafting surgery in rats.3

1.Bono, F., De Smet, F., Herbert, C.A., et al.Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric propertiesCancer Cell23(4)477-488(2013) 2.Dol-Gleizes, F., Delesque-Touchard, N., Marés, A.M., et al.A new synthetic FGF receptor antagonist inhibits arteriosclerosis in a mouse vein graft model and atherosclerosis in apolipoprotein E-deficient micePLoS One8(11)e80027(2013) 3.Huang, Q.-X., Liang, L.-D., Lan, Z.-C., et al.Effects of ssr128,129e on intimal hyperplasia in autogenous vein grafts of ratsShiyong Yixue Zazhi31(2)188-190(2015)

化学性质

Cas No. 848463-13-8 SDF
别名 SSR free acid
Canonical SMILES COC1=C2N(C(C(C3=CC=C(N)C(C(O)=O)=C3)=O)=C1C)C=CC=C2
分子式 C18H16N2O4 分子量 324.33
溶解度 Soluble in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 3.0833 mL 15.4164 mL 30.8328 mL
5 mM 0.6167 mL 3.0833 mL 6.1666 mL
10 mM 0.3083 mL 1.5416 mL 3.0833 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

质量
=
浓度
x
体积
x
分子量
 
 
 
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

计算

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % saline
计算重置

产品文档

Quality Control & SDS

View current batch: