Swertisin

Swertisin is a flavonoid C-glycoside that has been found in Swertia japonica and has diverse biological activities.^1,2,3 It inhibits sodium-glucose cotransporter 2 (SGLT2) in HEK293 cells when used at a concentration of 7.5 ?g/ml and is an adenosine A₁ receptor antagonist (IC₅₀ = 137 ?M).^1,2 Swertisin (0.2-5 ?M) inhibits hepatitis B virus (HBV) replication in HepG2 2.2.15 cells.³ It decreases blood glucose levels in a mouse model of diabetes induced by streptozotocin , as well as prevents scopolamine-induced increases in escape latency in the Morris water maze in mice.^1,2

1.Bhardwaj, G., Vakani, M., Srivastava, A., et al.Swertisin, a novel SGLT2 inhibitor, with improved glucose homeostasis for effective diabetes therapyArch. Biochem. Biophys.710108995(2021) 2.Lee, H.E., Jeon, S.J., Ryu, B., et al.Swertisin, a C-glucosylflavone, ameliorates scopolamine-induced memory impairment in mice with its adenosine A1 receptor antagonistic propertyBehav. Brain Res.306137-145(2016) 3.Xu, H.-Y., Ren, J.-H., Su, Y., et al.Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum MaximJ. Ethnopharmacol.257112787(2020)