Theaflavin-3-gallate
(Synonyms: 茶黄素-3-没食子酸酯) 目录号 : GC37779
A polyphenolic flavonoid with diverse biological activities
Cas No.:30462-34-1
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Theaflavin-3-gallate is a polyphenolic flavonoid that has been found in black tea (C. sinensis) and has diverse biological activities.1,2,3 It scavenges singlet oxygen and hydrogen peroxide, as well as superoxide and hydroxide radicals (IC50s = 0.86, 0.45, 21.7, and 32.49 ?M, respectively), in cell-free assays.1 Theaflavin-3-gallate is cytotoxic to, and induces apoptosis in, OVCAR-3 and A2780/CP70 ovarian cancer, but not non-cancerous IOSE 364 ovarian epithelial, cells when used at concentrations of 20 and 40 ?M.2 It reduces oxazolone-induced ear edema and serum and ear levels of TNF-α, IFN-γ, and IL-12 in an oxazolone-sensitized mouse model of delayed-type hypersensitivity when administered at a dose of 50 mg/kg.3
1.Wu, Y.-y., Li, W., Xu, Y., et al.Evaluation of the antioxidant effects of four main theaflavin derivatives through chemiluminescence and DNA damage analysesJ. Zhejiang. Univ. Sci. B.12(9)744-751(2011) 2.Gao, Y., Rankin, G.O., Tu, Y., et al.Inhibitory effects of the four main theaflavin derivatives found in black tea on ovarian cancer cellsAnticancer Res.36(2)643-651(2016) 3.Yoshino, K., Yamazaki, K., and Sano, M.Preventive effects of black tea theaflavins against mouse type IV allergyJ. Sci. Food Agric.90(12)1983-1987(2010)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 1.3955 mL | 6.9774 mL | 13.9548 mL |
| 5 mM | 0.2791 mL | 1.3955 mL | 2.791 mL |
| 10 mM | 0.1395 mL | 0.6977 mL | 1.3955 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。