Tricaprilin
(Synonyms: 三辛酸甘油酯,Trioctanoin; Glyceryl trioctanoate) 目录号 : GC37826
A triacylglycerol
Cas No.:538-23-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
1,2,3-Trioctanoyl glycerol is a triacylglycerol that contains octanoic acid at the sn-1, sn-2, and sn-3 positions. Dietary administration of 1,2,3-trioctanoyl glycerol (260 g/kg diet) increases hepatic and adipose tissue glucose-6-phosphate dehydrogenase (G6PDH), citrate cleavage enzyme (CCE), and malic enzyme activities in rats.1 It induces nuclear edema and cytolysis in tumor cells, but not normal hepatic cells, in a murine hepatic carcinoma model.2
1.Torii, S., Hwang, S.G., Matsui, T., et al.Comparative changes of lipogenic-related enzyme activities by dietary glycerol tricaprylate, tricaprate, trilaurate and trioleate in rat liver and adipose tissuesAnim. Sci. Tech.67(5)430-438(1996) 2.Burton, A.F.Oncolytic effects of fatty acids in mice and ratsAm. J. Clin. Nutr.53(4 Suppl)1082S-1086S(1991)
| Cas No. | 538-23-8 | SDF | |
| 别名 | 三辛酸甘油酯,Trioctanoin; Glyceryl trioctanoate | ||
| Canonical SMILES | CCCCCCCC(OCC(OC(CCCCCCC)=O)COC(CCCCCCC)=O)=O | ||
| 分子式 | C27H50O6 | 分子量 | 470.68 |
| 溶解度 | DMSO: 41.67 mg/mL (88.53 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.1246 mL | 10.6229 mL | 21.2459 mL |
| 5 mM | 0.4249 mL | 2.1246 mL | 4.2492 mL |
| 10 mM | 0.2125 mL | 1.0623 mL | 2.1246 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Modeling digestion, absorption, and ketogenesis after administration of Tricaprilin formulations to humans
Eur J Pharm Biopharm 2023 Jan;182:41-52.PMID:36470522DOI:10.1016/j.ejpb.2022.11.022.
At present, Tricaprilin is used as a ketogenic source for the management of mild to moderate Alzheimer's disease. After administration of the medium-chain triglyceride, Tricaprilin is hydrolyzed to octanoic acid and further metabolized to ketones, acting as an alternative energy substrate for the brain. In this investigation, we developed a physiologically-based biopharmaceutics model simulating in vivo processes following the peroral administration of Tricaprilin. The model includes multiple data sources to establish a partially verified framework for the simulation of plasma profiles. The input parameters were identified based on existing literature data and in vitro digestion studies. Model validation was conducted using the data from a phase I clinical trial. A partial parameter sensitivity analysis elucidated various influences on the plasma ketone levels that are mainly responsible for the therapeutic effects of Tricaprilin. Based on our findings, we concluded that dispersibility and lipolysis of Tricaprilin together with the gastric emptying patterns are limiting ketogenesis, while other steps such as the conversion of octanoic acid to ketone bodies play a minor role only.
Distribution of dimorphic yeast species in commercial extra virgin olive oil
Food Microbiol 2010 Dec;27(8):1035-42.PMID:20832682DOI:10.1016/j.fm.2010.07.005.
Recent microbiological research has demonstrated the presence of a rich microflora mainly composed of yeasts in the suspended fraction of freshly produced olive oil. Some of the yeasts are considered useful as they improve the organoleptic characteristics of the oil during preservation, whereas others are considered harmful as they can damage the quality of the oil through the hydrolysis of the triglycerides. However, some dimorphic species can also be found among the unwanted yeasts present in the oil, considered to be opportunistic pathogens to man as they have often been isolated from immunocompromised hospital patients. Present research demonstrates the presence of dimorphic yeast forms in 26% of the commercial extra virgin olive oil originating from different geographical areas, where the dimorphic yeasts are represented by 3-99.5% of the total yeasts. The classified isolates belonged to the opportunistic pathogen species Candida parapsilosis and Candida guilliermondii, while among the dimorphic yeasts considered not pathogenic to man, the Candida diddensiae species was highlighted for the first time in olive oil. The majority of the studied yeast strains resulted lipase positive, and can consequently negatively influence the oil quality through the hydrolysis of the triglycerides. Furthermore, all the strains showed a high level of affinity with some organic solvents and a differing production of biofilm in "vitro" corresponded to a greater or lesser hydrophobia of their cells. Laboratory trials indicated that the dimorphic yeasts studied are sensitive towards some components of the oil among which oleic acid, linoleic acid and triolein, whereas a less inhibiting effect was observed with Tricaprilin or when the total polyphenols extracted from the oil were used. The observations carried out on a scanning electron microscope (SEM), demonstrated the production of long un-branched pseudohyphae in all the tested dimorphic yeasts when cultivated on nutrient-deficient substrates.
[Isolation and characteristics of Penicillium roqueforti lipases]
Mikrobiologiia 1980 Nov-Dec;49(6):924-30.PMID:7207261doi
Lipase were isolated from Penicillium roqueforti 141, purified and their properties were studied. Proteins were precipitated with (NH4)2SO4 from the cultural broth of this organism, and then subjected to gel filtration through Sephadex G-100 and chromatography on DEAE-cellulose; the procedure yielded a purified preparation consisting of three lipolytically active proteins. Disc electrophoresis in polyacrylamide gel confirmed the homogeneity of the lipases. The molecular weights of the enzymes were 7930, 9100 and 11 420 respectively, according to the data of gel filtration through Sephadex G-150. The lipases differed in their substrate specificity. Lipase III was most active in hydrolysis of plant oils containing mainly unsaturated fatty acids. Lipase II most effectively hydrolyzed synthetic triglycerides containing saturated fatty acids, in particular, tricaproin, Tricaprilin and trimyristin. Tributyrin was more actively hydrolyzed with lipase I as compared to lipases II and III.
[Benzopyrene (BaP) implants into the glottic mucous membrane of hamsters]
HNO 1983 Mar;31(3):91-5.PMID:6305889doi
For testing the effect of benzo (a) pyrene (BaP) on glottical epithelium European hamsters were used. With laryngofissure hamsters larynges had been opened and a mixture of Tricaprilin, beewax and 1 mg BaP was implanted into a pocket formed by mucous membrane of one vocal fold. Compared to typical histology in smoker's larynx, squamous metaplasia and dysplasia and in one case papillary polyps could be described. No squamous cell carcinomata was found.