Valifenalate
(Synonyms: 霜霉灭,IR5885; Valiphenal) 目录号 : GC37883
Valifenalate(IR5885; Valiphenal) 为抗真菌剂，可用于葡萄，西红柿和其他蔬菜等高价值作物，可有效对抗各种霉菌。
Cas No.:283159-90-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Valifenalate(IR5885; Valiphenal), which is approved for application on high-value crops such as grapes, tomatoes and other vegetables, is effective against various types of mildew and is currently marketed primarily under the Valis moniker; insecticide agent.
[1]. HOFFMAN, Thomas, James., et al. FUNGICIDAL COMPOSITIONS. WO 2018 219773 A1
| Cas No. | 283159-90-0 | SDF | |
| 别名 | 霜霉灭,IR5885; Valiphenal | ||
| Canonical SMILES | O=C([C@H](C(C)C)NC(OC(C)C)=O)NC(C1=CC=C(Cl)C=C1)CC(OC)=O | ||
| 分子式 | C19H27ClN2O5 | 分子量 | 398.88 |
| 溶解度 | DMSO: ≥ 41 mg/mL (102.79 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.507 mL | 12.5351 mL | 25.0702 mL |
| 5 mM | 0.5014 mL | 2.507 mL | 5.014 mL |
| 10 mM | 0.2507 mL | 1.2535 mL | 2.507 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Modification of the existing maximum residue levels for Valifenalate in various crops
EFSA J 2018 Jun 14;16(6):e05289.PMID:32625929DOI:10.2903/j.efsa.2018.5289.
In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Belchim Crop Protection NV/SA submitted a request to the competent national authority in Hungary to modify the existing maximum residue levels (MRLs) for the active substance Valifenalate in various crops. The data submitted in support of the request were found to be sufficient to derive MRL proposals for lettuces, tomatoes, aubergines, onions, shallots and garlic. Adequate analytical methods for enforcement are available to control the residues of Valifenalate on the commodities under consideration at the validated limit of quantification (LOQ) of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that the long-term intake of residues resulting from the use of Valifenalate according to the reported agricultural practices is unlikely to present a risk to consumer health. The short-term intake was not carried out since no acute reference dose (ARfD) is established for Valifenalate. The reliable end points, appropriate for use in regulatory risk assessment are presented.
Review of the existing maximum residue levels for Valifenalate according to Article 12 of Regulation (EC) No 396/2005
EFSA J 2021 May 10;19(5):e06591.PMID:33976719DOI:10.2903/j.efsa.2021.6591.
According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide Valifenalate. To assess the occurrence of Valifenalate residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Commission Regulation (EU) No 188/2011, as well as European authorisations reported by Member States and the UK (including the supporting residues data). Based on the assessment of the available data, MRL proposals were derived and a consumer risk assessment was carried out. Although no apparent risk to consumers was identified, some information required by the regulatory framework was missing. Hence, the consumer risk assessment is considered indicative only and one MRL proposal derived by EFSA still requires further consideration by risk managers.
Scientific support for preparing an EU position for the 52nd Session of the Codex Committee on Pesticide Residues (CCPR)
EFSA J 2021 Aug 17;19(8):e06766.PMID:34429776DOI:10.2903/j.efsa.2021.6766.
In accordance with Article 43 of Regulation (EC) 396/2005, EFSA received a request from the European Commission to provide support for the preparation of the EU position for 52nd session of the Codex Committee on Pesticide Residues (CCPR). In 2019, JMPR evaluated 20 active substances regarding the setting of toxicological reference values to be used in consumer risk assessment (acetochlor, boscalid, chlorothalonil, cyprodinil, dicamba, mesotrione, metaflumizone, thiabendazole, afidopyropen, buprofezin, clethodim, dimethoate, metconazole, omethoate, pyflubumide, pyridate, pyrifluquinazon, tolclofos-methyl, triflumuron, Valifenalate) and 47 active substance regarding the setting of Maximum Residue Limits (MRLs) (acetochlor, azoxystrobin, boscalid, chlorantraniliprole, chlorothalonil, cyantraniliprole, cyprodinil, dicamba, fenazaquin, flonicamid, flupyradifurone, fosetyl-Al, glyphosate, mesotrione, metaflumizone, S-methoprene, pendimethalin, spirotetramat, tebuconazole, thiabendazole, acetamiprid, afidopyropen, benzovindiflupyr, bifenthrin, buprofezin, carbendazim, clethodim, cyclaniliprole, cypermethrins, dimethoate, fluazifop-p-butyl, fluensulfone, kresoxim-methyl, mandestrobin, metconazole, omethoate, penthiopyrad, picoxystrobin, pydiflumetofen, pyflubumide, pyrifluquinazon, pyriofenone, pyriproxyfen, tolclofos-methyl, tolfenpyrad, triflumuron, Valifenalate). EFSA prepared comments on the Codex MRL proposals and the proposed toxicological reference values. In addition, EFSA provided the views on follow-up assessments of JMPR on pesticides where specific concerns were raised in the previous CCPR meetings. The current report should serve as the basis for deriving the EU position for the CCPR meeting.