Vicenin 2
(Synonyms: 维采宁 2) 目录号 : GC37902
A flavonoid glycoside with diverse biological activities
Cas No.:23666-13-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Vicenin-2 is a polyketide synthase-derived flavonoid glycoside that has been found in C. subternata and has diverse biological activities.1,2,3,4,5 It inhibits thrombin-induced aggregation of isolated mouse platelets when used at concentrations ranging from 2 to 30 ?M, as well as increases tail bleeding time in mice when administered at a dose of 35.7 ?g/animal.2 Vicenin-2 (1 mg/kg) reduces tumor growth in a PC3 prostate cancer mouse xenograft model.3 It decreases trabecular separation, as well as increases trabecular thickness and area, in an ovariectomized rat model of osteoporosis.4 Vicenin-2 (50 mg/kg) decreases ulceration and increases colon weight and length in a mouse model of colitis induced by dextran sulfate .5
1.Kitamura, K., Ando, Y., Matsumoto, T., et al.Total synthesis of aryl C-glycoside natural products: Strategies and tacticsChem. Rev.118(4)1495-1598(2018) 2.Lee, W., and Bae, J.-S.Antithrombotic and antiplatelet activities of vicenin-2Blood Coagul. Fibrinolysis26(6)628-634(2015) 3.Nagaprashantha, L.D., Vatsyayan, R., Singhal, J., et al.Anti-cancer effects of novel flavonoid vicenin-2 as a single agent and in synergistic combination with docetaxel in prostate cancerBiochem. Pharmacol.82(9)1100-1109(2011) 4.Zhang, Z., Zhao, Q., Liu, T., et al.Effect of vicenin-2 on ovariectomy-induced osteoporosis in ratsBiomed. Pharmacother.129110474(2020) 5.Yin, Y., Ye, L., Niu, Z., et al.Anti-inflammatory effects of Vicenin-2 on dextran sulfate sodium-induced colitis in miceDrug Dev. Res.80(5)546-555(2019)
| Cas No. | 23666-13-9 | SDF | |
| 别名 | 维采宁 2 | ||
| Canonical SMILES | OC1=C([C@@H]([C@@H]([C@@H](O)[C@@H]2O)O)O[C@@H]2CO)C(O)=C3C(OC(C4=CC=C(O)C=C4)=CC3=O)=C1[C@@H]([C@@H]([C@@H](O)[C@@H]5O)O)O[C@@H]5CO | ||
| 分子式 | C27H30O15 | 分子量 | 594.52 |
| 溶解度 | DMSO : 33.33 mg/mL (56.06 mM; Need ultrasonic); H2O : < 0.1 mg/mL (insoluble) | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.682 mL | 8.4101 mL | 16.8203 mL |
| 5 mM | 0.3364 mL | 1.682 mL | 3.3641 mL |
| 10 mM | 0.1682 mL | 0.841 mL | 1.682 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Vicenin 2 isolated from Artemisia capillaris exhibited potent anti-glycation properties
Food Chem Toxicol 2014 Jul;69:55-62.PMID:24713265DOI:10.1016/j.fct.2014.03.042.
Vicenin 2, isolated from a traditionally used medicinal plant Artemisia capillaris, is a 6,8-di-C-glucoside of apigenin which has been previously reported to possess a wide variety of pharmacological activities including antioxidant, anti-inflammatory, anti-cancer, and hepatoprotective. However, there have not been any reports concerning its anti-diabetic potential until now. Therefore, in the present study, we evaluated the anti-diabetic potential of Vicenin 2 via α-glucosidase, protein tyrosine phosphatase 1B (PTP1B), rat lens aldose reductase (RLAR), and advanced glycation end products (AGE) formation inhibitory assays. Vicenin 2 strongly inhibited α-glucosidase, PTP1B, and RLAR in the corresponding assays. In addition, Vicenin 2 inhibited the formation of both fluorescent AGE and nonfluorescent AGE, e.g., CML, as well as the level of fructosamine in glucose-fructose-induced bovine serum albumin (BSA) glycation. In the test system, Vicenin 2 suppressed glycation-induced protein oxidation by attenuating the formation of protein carbonyl groups as well as by inhibiting the modification of protein thiol groups. Moreover, Vicenin 2 was found to be a potent inhibitor of glycation-induced formation of amyloid cross-β structures in BSA. Taken together, Vicenin 2 might be a useful lead for the development of multiple target-oriented therapeutic modalities for the treatment of diabetes and diabetes-associated complications.
Testing of Perilla frutescens extract and Vicenin 2 for their antispasmodic effect
Phytomedicine 2013 Mar 15;20(5):427-31.PMID:23357362DOI:10.1016/j.phymed.2012.12.018.
Gastrointestinal discomfort is frequently observed. The effects of Perilla frutescens extract and Vicenin 2 (a compound in this extract) were assayed in rat ileum with or without stimulation with acetylcholine or Ba(2+). Both had no direct spasmolytic effect, but both decreased acetylcholine- or Ba(2+)-induced contraction of rat ileum indicating an antispasmodic effect. This is valuable because effects were only observed when spasms were induced and may disturb the patient. The extract and the compound may be used to maintain and improve gut health.