Vicenin 2
(Synonyms: 维采宁 2) 目录号 : GC37902
A flavonoid glycoside with diverse biological activities
Cas No.:23666-13-9
Sample solution is provided at 25 µL, 10mM.
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Vicenin-2 is a polyketide synthase-derived flavonoid glycoside that has been found in C. subternata and has diverse biological activities.1,2,3,4,5 It inhibits thrombin-induced aggregation of isolated mouse platelets when used at concentrations ranging from 2 to 30 ?M, as well as increases tail bleeding time in mice when administered at a dose of 35.7 ?g/animal.2 Vicenin-2 (1 mg/kg) reduces tumor growth in a PC3 prostate cancer mouse xenograft model.3 It decreases trabecular separation, as well as increases trabecular thickness and area, in an ovariectomized rat model of osteoporosis.4 Vicenin-2 (50 mg/kg) decreases ulceration and increases colon weight and length in a mouse model of colitis induced by dextran sulfate .5
1.Kitamura, K., Ando, Y., Matsumoto, T., et al.Total synthesis of aryl C-glycoside natural products: Strategies and tacticsChem. Rev.118(4)1495-1598(2018) 2.Lee, W., and Bae, J.-S.Antithrombotic and antiplatelet activities of vicenin-2Blood Coagul. Fibrinolysis26(6)628-634(2015) 3.Nagaprashantha, L.D., Vatsyayan, R., Singhal, J., et al.Anti-cancer effects of novel flavonoid vicenin-2 as a single agent and in synergistic combination with docetaxel in prostate cancerBiochem. Pharmacol.82(9)1100-1109(2011) 4.Zhang, Z., Zhao, Q., Liu, T., et al.Effect of vicenin-2 on ovariectomy-induced osteoporosis in ratsBiomed. Pharmacother.129110474(2020) 5.Yin, Y., Ye, L., Niu, Z., et al.Anti-inflammatory effects of Vicenin-2 on dextran sulfate sodium-induced colitis in miceDrug Dev. Res.80(5)546-555(2019)
| Cas No. | 23666-13-9 | SDF | |
| 别名 | 维采宁 2 | ||
| Canonical SMILES | OC1=C([C@@H]([C@@H]([C@@H](O)[C@@H]2O)O)O[C@@H]2CO)C(O)=C3C(OC(C4=CC=C(O)C=C4)=CC3=O)=C1[C@@H]([C@@H]([C@@H](O)[C@@H]5O)O)O[C@@H]5CO | ||
| 分子式 | C27H30O15 | 分子量 | 594.52 |
| 溶解度 | DMSO : 33.33 mg/mL (56.06 mM; Need ultrasonic); H2O : < 0.1 mg/mL (insoluble) | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.682 mL | 8.4101 mL | 16.8203 mL |
| 5 mM | 0.3364 mL | 1.682 mL | 3.3641 mL |
| 10 mM | 0.1682 mL | 0.841 mL | 1.682 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet