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YS-49 monohydrate Sale

目录号 : GC37955

An inhibitor of platelet aggregation

YS-49 monohydrate Chemical Structure

规格 价格 库存 购买数量
10mg
¥1,105.00
现货
50mg
¥3,884.00
现货
100mg 待询 待询
200mg 待询 待询

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Sample solution is provided at 25 µL, 10mM.

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产品描述

YS-49 is an inhibitor of platelet aggregation.1 It inhibits ADP-, collagen-, or epinephrine-induced platelet aggregation in isolated human platelets (IC50s = 730, 92, and 3.4 ?M, respectively). YS-49 also inhibits platelet aggregation and production of thromboxane A2 (TXA2) induced by arachidonic acid in isolated rat platelets (IC50s = 3.3 and 32.8 ?M, respectively).2 It reduces LPS-induced contractions in isolated endothelium-denuded rat aortic strips in a concentration-dependent manner.3 YS-49 (50 mg/kg) decreases thrombus weight in a rat model of arterio-venous shunt thrombosis.1 It increases survival in a mouse model of septicemia induced by LPS when administered at doses of 10 and 20 mg/kg.3

1.Yun-Choi, H.S., Pyo, M.K., Park, K.M., et al.Antithrombotic effects of YS-49 and YS-51--1-naphthylmethyl analogs of higenamineThromb. Res.104(4)249-255(2001) 2.Pyo, M.K., Kim, J.M., Jin, J.-L., et al.Effects of higenamine and its 1-naphthyl analogs, YS-49 and YS-51, on platelet TXA2 synthesis and aggregationThromb. Res.120(1)81-86(2007) 3.Kang, Y.J., Koo, E.B., Lee, Y.S., et al.Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophagesBr. J. Pharmacol.128(2)357-364(1999)

Chemical Properties

Cas No. SDF
Canonical SMILES OC1=CC2=C(C(CC3=C4C=CC=CC4=CC=C3)NCC2)C=C1O.O.Br
分子式 C20H22BrNO3 分子量 404.3
溶解度 Soluble in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.4734 mL 12.3671 mL 24.7341 mL
5 mM 0.4947 mL 2.4734 mL 4.9468 mL
10 mM 0.2473 mL 1.2367 mL 2.4734 mL
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