β-Boswellic acid
(Synonyms: β-乳香酸) 目录号 : GC38000
A pentacyclic triterpene with diverse bioactivities
Cas No.:631-69-6
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Quality Control & SDS
- View current batch:
- Purity: >98.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
β-Boswellic acid is a pentacyclic triterpene originally isolated from Boswellia that has diverse bioactivities.1 It inhibits 5-lipoxygenase (5-LO) with an IC50 value of approximately 5 ?M but is less potent than its derivative 3-acetyl-11-keto-β-boswellic acid .2 It inhibits cell proliferation in HL-60 cells with IC50 values of 3.7, 7.1, and 6.3 ?M for DNA, RNA, and protein synthesis, respectively.3 In human umbilical vein endothelial cells (HUVECs) transiently deprived of oxygen and glucose, β-boswellic acid increases nitric oxide and increases phosphorylation of enzyme nitric oxide synthase (eNOS).4 It also increases calcium mobilization in platelets at concentrations ≥3 ?M and induces platelet aggregation (EC50 = 8 ?M).5
1.Ammon, H.P., Safayhi, H., Mack, T., et al.Mechanism of antiinflammatory actions of curcumine and boswellic acidsJ. Ethnopharmacol.38(2-3)113-119(1993) 2.Safayhi, H., Mack, T., Sabieraj, J., et al.Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenaseJ. Pharmacol. Exp. Ther.261(3)1143-1146(1992) 3.Shao, Y., Ho, C.-T., Chin, C.-K., et al.Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culturePlanta Med.64(4)328-331(1998) 4.Wang, M., Chen, M., Ding, Y., et al.Pretreatment with β-boswellic acid improves blood stasis induced endothelial dysfunction: Role of eNOS activationSci. Rep.5:15357(2015) 5.Siemoneit, U., Tausch, L., Poeckel, D., et al.Defined structure-activity relationships of boswellic acids determine modulation of Ca2+ mobilization and aggregation of human platelets by Boswellia serrata extractsPlanta Med.83(12-13)1020-1027(2017)
| Cas No. | 631-69-6 | SDF | |
| 别名 | β-乳香酸 | ||
| Canonical SMILES | C[C@]12[C@@](CC=C3[C@]2(CC[C@]4(C)[C@@]3([H])[C@H]([C@H](C)CC4)C)C)([H])[C@@]5([C@@]([C@](C)([C@H](O)CC5)C(O)=O)([H])CC1)C | ||
| 分子式 | C30H48O3 | 分子量 | 456.7 |
| 溶解度 | DMF: 25 mg/ml,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:2): 0.30 mg/ml,Ethanol: 5 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.1896 mL | 10.9481 mL | 21.8962 mL |
| 5 mM | 0.4379 mL | 2.1896 mL | 4.3792 mL |
| 10 mM | 0.219 mL | 1.0948 mL | 2.1896 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。