DHPG
(Synonyms: DL-Α-(3,5-二羟基苯基)甘氨酸,(RS)-3,5-DHPG) 目录号 : GC38029An agonist of group I mGluRs
Cas No.:146255-66-5
Sample solution is provided at 25 µL, 10mM.
(R,S)-3,5-DHPG is an agonist of group I metabotropic glutamate receptors (mGluRs).1 It induces phosphoinositol hydrolysis in MCB3901, also known as AV12-664, cells expressing human mGluR1a and mGluR5a in a concentration-dependent manner. (R,S)-3,5-DHPG (10 ?M) potentiates NMDA-induced depolarizations in rat hippocampal slices. Intrathecal administration of (R,S)-3,5-DHPG (300 nmol/animal) increases mean blood pressure in anesthetized rats.2 Intracerebroventricular administration of (R,S)-3,5-DHPG (1.5 ?mol/animal) induces seizures in rats.3
1.Fitzjohn, S.M., Bortolotto, Z.A., Palmer, M.J., et al.The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticityNeuropharmacology37(12)144-1458(1998) 2.S.M., C., and García, M.d.C.Activation of spinal metabotropic glutamate receptors elicits cardiovascular responses in pentobarbital anesthetized ratsNaunyn Schmiedebergs Arch Pharmacol.366(4)343-349(2002) 3.Camón, L., Vives, P., de Vera, N., et al.Seizures and neuronal damage induced in the rat by activation of group I metabotropic glutamate receptors with their selective agonist 3,5-dihydroxyphenylglycineJ. Neurosci. Res.51(3)339-348(1998)
Cas No. | 146255-66-5 | SDF | |
别名 | DL-Α-(3,5-二羟基苯基)甘氨酸,(RS)-3,5-DHPG | ||
Canonical SMILES | O=C(O)C(N)C1=CC(O)=CC(O)=C1 | ||
分子式 | C8H9NO4 | 分子量 | 183.16 |
溶解度 | DMSO: 1 mg/mL (5.46 mM); Water: 1 mg/mL (5.46 mM) | 储存条件 | Store at -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
1 mg | 5 mg | 10 mg | |
1 mM | 5.4597 mL | 27.2985 mL | 54.5971 mL |
5 mM | 1.0919 mL | 5.4597 mL | 10.9194 mL |
10 mM | 0.546 mL | 2.7299 mL | 5.4597 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet