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Fraxinellone Sale

(Synonyms: 梣酮) 目录号 : GC38044

A liminoid degradant with diverse biological activities

Fraxinellone Chemical Structure

Cas No.:28808-62-0

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥616.00
现货
5mg
¥560.00
现货
10mg
¥840.00
现货
20mg
¥1,400.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

Fraxinellone is a liminoid degradant that has been found in D. dasycarpus and has diverse biological activities.1,2,3 It has antifeedant activity against, and inhibits development of, armyworm (M. separata) larvae when applied to fresh wheat leaves at concentrations of 5, 10, or 20 mg/ml.1 Fraxinellone (6.25, 12.5, and 25 ?M) reduces LPS-induced nuclear translocation of the NF-κB subunit p65, as well as inhibits LPS-induced production of nitric oxide (NO) and prostaglandin E2 in RAW 264.7 cells.2 It reduces tumor growth in an A549 mouse xenograft model when administered at doses of 30 or 100 mg/kg.3

1.Lü, M., Wu, W., and Liu, H.Insecticidal and feeding deterrent effects of fraxinellone from Dictamnus dasycarpus against four major pestsMolecules18(3)2754-2762(2013) 2.Kim, J.-H., Park, Y.-M., Shin, J.-S., et al.Fraxinellone inhibits lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by negatively regulating nuclear factor-kappa B in RAW 264.7 macrophages cellsBiol. Pharm. Bull.32(6)1062-1068(2009) 3.Xing, Y., Mi, C., Wang, Z., et al.Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3Pharmacol. Res.135166-180(2018)

化学性质

Cas No. 28808-62-0 SDF
别名 梣酮
Canonical SMILES O=C1O[C@@H](C2=COC=C2)[C@]3(C)CCCC(C)=C31
分子式 C14H16O3 分子量 232.28
溶解度 DMSO: 100 mg/mL (430.51 mM) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.3051 mL 21.5257 mL 43.0515 mL
5 mM 0.861 mL 4.3051 mL 8.6103 mL
10 mM 0.4305 mL 2.1526 mL 4.3051 mL
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