Fraxinellone

Fraxinellone is a liminoid degradant that has been found in D. dasycarpus and has diverse biological activities.^1,2,3 It has antifeedant activity against, and inhibits development of, armyworm (M. separata) larvae when applied to fresh wheat leaves at concentrations of 5, 10, or 20 mg/ml.¹ Fraxinellone (6.25, 12.5, and 25 ?M) reduces LPS-induced nuclear translocation of the NF-κB subunit p65, as well as inhibits LPS-induced production of nitric oxide (NO) and prostaglandin E₂ in RAW 264.7 cells.² It reduces tumor growth in an A549 mouse xenograft model when administered at doses of 30 or 100 mg/kg.³

1.Lü, M., Wu, W., and Liu, H.Insecticidal and feeding deterrent effects of fraxinellone from Dictamnus dasycarpus against four major pestsMolecules18(3)2754-2762(2013) 2.Kim, J.-H., Park, Y.-M., Shin, J.-S., et al.Fraxinellone inhibits lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by negatively regulating nuclear factor-kappa B in RAW 264.7 macrophages cellsBiol. Pharm. Bull.32(6)1062-1068(2009) 3.Xing, Y., Mi, C., Wang, Z., et al.Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3Pharmacol. Res.135166-180(2018)