Gitogenin
(Synonyms: 支脱皂苷元) 目录号 : GC38046
A sapogenin with enzyme inhibitory and hormone-releasing activities
Cas No.:511-96-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Gitogenin is a sapogenin that has been found in T. foenum-graecum and has enzyme inhibitory and hormone-releasing activities.1,2 It is an inhibitor of UDP-glucuronosyltransferase (UGT) isoform UGT1A4 (IC50 = 0.69 ?M).1 Gitogenin (20 ?g/ml) stimulates the release of growth hormone in primary rat pituitary cells.2
1.Xu, M., Dong, P., Tian, X., et al.Drug interaction study of natural steroids from herbs specifically toward human UDP-glucuronosyltransferase (UGT) 1A4 and their quantitative structure activity relationship (QSAR) analysis for predictionPharmacol. Res.110139-150(2016) 2.Shim, S.H., Lee, E.J., Kim, J.S., et al.Rat growth-hormone release stimulators from fenugreek seedsChem. Biodivers.5(9)1753-1761(2008)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.3114 mL | 11.557 mL | 23.1139 mL |
| 5 mM | 0.4623 mL | 2.3114 mL | 4.6228 mL |
| 10 mM | 0.2311 mL | 1.1557 mL | 2.3114 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。