Daphnoretin
(Synonyms: 西瑞香素,Dephnoretin; Thymelol) 目录号 : GC38186
A coumarin with diverse biological activities
Cas No.:2034-69-7
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Daphnoretin is a coumarin that has been found in W. indica and has diverse biological activities.1,2,3 It induces aggregation of washed rabbit platelets (EC50 = 17.2 μM), an effect that is reversed by the protein kinase C (PKC) inhibitor staurosporine .1 Daphnoretin is active against respiratory syncytial virus (RSV) in a plaque reduction assay using HEp-2 cells (IC50 = 5.87 μg/ml).2 It halts the cell cycle at the G2/M phase, induces apoptosis, and inhibits proliferation of human osteosarcoma (HOS) cells (IC50 = 3.89 μM).3 Daphnoretin also reduces proliferation, invasion, and migration of HCT116 colon cancer cells in a concentration-dependent manner.4
1.Feng, N.K.O., Chang, Y.L., Kuo, Y.H., et al.Daphnoretin, a new protein kinase C activator isolated from Wikstroemia indica C.A. MeyBiochem J.295(Pt 1)321-327(1993) 2.Ho, W.-S., Xue, J.-Y., Sun, S.S.M., et al.Antiviral activity of daphnoretin isolated from Wikstroemia indicaPhytother. Res.24(5)657-661(2010) 3.Gu, S., and He, J.Daphnoretin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cellsMolecules17(1)598-612(2012) 4.Yu, S., Guo, H., Gao, X., et al.Daphnoretin: An invasion inhibitor and apoptosis accelerator for colon cancer cells by regulating the Akt signal pathwayBiomed. Pharmacother.1111013-1021(2019)
| Cas No. | 2034-69-7 | SDF | |
| 别名 | 西瑞香素,Dephnoretin; Thymelol | ||
| Canonical SMILES | O=C1C(OC2=CC=C(C(O3)=C2)C=CC3=O)=CC4=CC(OC)=C(O)C=C4O1 | ||
| 分子式 | C19H12O7 | 分子量 | 352.29 |
| 溶解度 | DMF: 25 mg/ml,DMSO: 25 mg/ml,Ethanol: partially soluble,PBS (pH >10.2): Partially soluble | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.8386 mL | 14.1929 mL | 28.3857 mL |
| 5 mM | 0.5677 mL | 2.8386 mL | 5.6771 mL |
| 10 mM | 0.2839 mL | 1.4193 mL | 2.8386 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet