Lithospermic acid
(Synonyms: 紫草酸; (+)-Lithospermic acid) 目录号 : GC38187
A polyphenol with diverse biological activities
Cas No.:28831-65-4
Sample solution is provided at 25 µL, 10mM.
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Lithospermic acid is a polyphenol that has been found in S. miltiorrhiza and has diverse biological activities.1,2 It inhibits xanthine oxidase (IC50 = 5.2 ?g/ml) and scavenges DPPH radicals in cell-free assays (IC50 = 23.2 ?g/ml). It also inhibits the production of reactive oxygen species (ROS) induced by phorbol 12-myristate 13-acetate in isolated human neutrophils in a concentration-dependent manner.1 Lithospermic acid inhibits 3'-processing and 3'-joining to target DNA by HIV-1 integrase in cell-free assays (IC50s = 0.83 and 0.48 ?M, respectively).3 It also inhibits acute HIV-1 infection of H9 human lymphoma cells (IC50 = 2 ?M) without inducing cytotoxicity. Lithospermic acid (100 mg/kg) prevents carbon tetrachloride-induced hepatic necrosis in mice.2
1.Liu, X., Chen, R., Shang, Y., et al.Lithospermic acid as a novel xanthine oxidase inhibitor has anti-inflammatory and hypouricemic effects in ratsChem. Biol. Interact.176(2-3)137-142(2008) 2.Chan, K.W.K., and Ho, W.S.Anti-oxidative and hepatoprotective effects of lithospermic acid against carbon tetrachloride-induced liver oxidative damage in vitro and in vivoOncol. Rep.34(2)673-680(2015) 3.Abd-Elazem, I.S., Chen, H.S., Bates, R.B., et al.Isolation of two highly potent and non-toxic inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase from Salvia miltiorrhizaAntiviral Res.55(1)91-106(2002)
| Cas No. | 28831-65-4 | SDF | |
| 别名 | 紫草酸; (+)-Lithospermic acid | ||
| Canonical SMILES | O=C([C@@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=C(O)C=CC(/C=C/C(O[C@@H](C(O)=O)CC4=CC=C(O)C(O)=C4)=O)=C13)O | ||
| 分子式 | C27H22O12 | 分子量 | 538.46 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C,protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.8571 mL | 9.2857 mL | 18.5715 mL |
| 5 mM | 0.3714 mL | 1.8571 mL | 3.7143 mL |
| 10 mM | 0.1857 mL | 0.9286 mL | 1.8571 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet