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SX-682 Sale

目录号 : GC38204

SX-682 is an orally bioavailable small-molecule allosteric inhibitor of CXCR1 and CXCR2 that blocks tumor MDSC recruitment and enhances T cell activation and antitumor immunity.

SX-682 Chemical Structure

Cas No.:1648843-04-2

规格 价格 库存 购买数量
1mg
¥251.00
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5mg
¥588.00
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10mg
¥884.00
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25mg
¥1,653.00
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50mg
¥2,717.00
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100mg
¥4,433.00
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Sample solution is provided at 25 µL, 10mM.

Description

SX-682 is an orally bioavailable small-molecule allosteric inhibitor of CXCR1 and CXCR2 that blocks tumor MDSC recruitment and enhances T cell activation and antitumor immunity.

Whole tumor accumulation of CXCL1 in vivo in MOC1 and LLC tumors is significantly greater than oral mucosa and normal lung, respectively, and not diminished with SX-682 treatment. Plasma accumulation of CXCL1 is greater in tumor-bearing mice compared with naive for both models and increases following SX-682 treatment. Treatment of mice bearing MOC1 or LLC tumors with SX-682 beginning 10 or 20 days after tumor initiation does not alter CXCR1 or CXCR2 expression on tumor cells in vivo.[2] Following in vivo SX-682 treatment, tumor PMN-MDSC expression of cell surface TGF-β or superoxide dismutase 1/2 genes, responsible for the generation of H2O2, is not significantly altered.[3]

[1] Xin Lu, et al. Nature. 2017 Mar 30;543(7647):728-732. [2] Lillian Sun, et al. JCI Insight. 2019 Apr 4;4(7):e126853. [3] Sarah Greene, et al. Clin Cancer Res. 2020 Mar 15;26(6):1420-1431.

化学性质

Cas No. 1648843-04-2 SDF
Canonical SMILES O=C(NC1=CC=C(F)C=C1)C(C=N2)=CN=C2SCC3=CC(OC(F)(F)F)=CC=C3B(O)O
分子式 C19H14BF4N3O4S 分子量 467.2
溶解度 DMSO: 250 mg/mL (535.10 mM) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.1404 mL 10.7021 mL 21.4041 mL
5 mM 0.4281 mL 2.1404 mL 4.2808 mL
10 mM 0.214 mL 1.0702 mL 2.1404 mL
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