Dextran
(Synonyms: 葡聚糖; Dextran 40) 目录号 : GC38241
Dextran (Dextran 40, Macrodex) is a kind of biocompatible, nontoxic and nonimmunogenic biological substance that has been widely used in drug-delivery systems.
Cas No.:9004-54-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Dextran (Dextran 40, Macrodex) is a kind of biocompatible, nontoxic and nonimmunogenic biological substance that has been widely used in drug-delivery systems.
[1] Gangliang Huang, Hualiang Huang. Nanomedicine (Lond). 2018 Dec;13(24):3149-3158.
| Cas No. | 9004-54-0 | SDF | |
| 别名 | 葡聚糖; Dextran 40 | ||
| Canonical SMILES | [Dextran] | ||
| 分子式 | 分子量 | 40000 | |
| 溶解度 | H2O : 100 mg/mL (2.50 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 0.025 mL | 0.125 mL | 0.25 mL |
| 5 mM | 0.005 mL | 0.025 mL | 0.05 mL |
| 10 mM | 0.0025 mL | 0.0125 mL | 0.025 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Acetalated Dextran based nano- and microparticles: synthesis, fabrication, and therapeutic applications
Chem Commun (Camb) 2021 Apr 29;57(35):4212-4229.PMID:33913978DOI:10.1039/d1cc00811k.
Acetalated Dextran (Ac-DEX) is a pH-responsive Dextran derivative polymer. Prepared by a simple acetalation reaction, Ac-DEX has tunable acid-triggered release profile. Despite its relatively short research history, Ac-DEX has shown great potential in various therapeutic applications. Furthermore, the recent functionalization of Ac-DEX makes versatile derivatives with additional properties. Herein, we summarize the cutting-edge development of Ac-DEX and related polymers. Specifically, we focus on the chemical synthesis, nano- and micro-particle fabrication techniques, the controlled-release mechanisms, and the rational design Ac-DEX-based of drug delivery systems in various biomedical applications. Finally, we briefly discuss the challenges and future perspectives in the field.
Application of Dextran as nanoscale drug carriers
Nanomedicine (Lond) 2018 Dec;13(24):3149-3158.PMID:30516091DOI:10.2217/nnm-2018-0331.
Dextran is a kind of biocompatible, nontoxic and nonimmunogenic biological substance that has been widely used in drug-delivery systems. With further research and understanding of Dextran and its derivatives, people can more precisely control the sequence of Dextran by chemical and biosynthetic methods as needed, and modify various structures to improve the properties of Dextran, such as hydrophilicity, hydrophobicity, temperature sensitivity, pH sensitivity and ionic strength sensitivity, which will further expand the application of Dextran and its derivatives in drug-delivery systems. Herein, the application of Dextran and its derivatives in gene transfection and drug delivery was summarized and analyzed, and the problems were studied. At the same time, its application prospects are forecasted.
Acetalated Dextran: A Tunable and Acid-Labile Biopolymer with Facile Synthesis and a Range of Applications
Chem Rev 2017 Feb 8;117(3):1915-1926.PMID:28032507DOI:10.1021/acs.chemrev.6b00532.
Acetalated Dextran (Ac-DEX) is a tunable acid-labile biopolymer with facile synthesis, aptly designed for the formulation of microparticles for vaccines and immune modulation. Tunability of degradation is achieved based on the kinetics of reaction and the molecular weight of the parent Dextran polymer. This tunability translated to differential rates of activation of CD8+ T cells in an in vitro ovalbumin model and illustrated that acid-labile polymer can activate CD8+ T cells at an increased rate compared to acid-insensitive polymers. In addition, Ac-DEX has been used to encapsulate small molecules, deliver nucleotides, transport inorganic molecules, formulate immune modulating therapies and vaccines, and trigger pH responsive constructs for therapy. Here we highlight the properties and results of Ac-DEX nano-/microparticles as well as the use of the polymer in other constructs and chemistries.
Efficacy of Dextran solutions in vascular surgery
Vasc Endovascular Surg 2004 Nov-Dec;38(6):483-91.PMID:15592628DOI:10.1177/153857440403800601.
The purpose of this paper is to discuss the role and efficacy of Dextran in vascular procedures using evidence-based data from the review of surgical literature. A medline search using "Dextran,'' "vascular surgery,'' and "antiplatelet therapy'' as keywords was performed for English-language articles. Further references were obtained through cross-referencing the bibliography cited in each work. Dextran is commonly used in carotid endarterectomy (CEA) patients where the embolic rate is reduced by 46%, resulting in fewer procedure-related strokes. As a prophylactic agent against thrombosis, multiple randomized studies have reported its benefit over other antithrombotic medications. Dextran is also particularly useful in "difficult'' infragenicular lower extremity bypasses where artificial grafts (such as polytetrafluoroethylene [PTFE] or umbilical vein) are used in the setting of poor outflow vessels, or those with composite grafts and small-caliber venous conduits. Distal bypasses with adjunctive procedures (eg, arteriovenous fistula or anastomotic cuffs) also have a better outcome with the addition of Dextran. Dextran has numerous important implications in vascular surgery, in particular with CEA patients or "difficult'' infragenicular bypasses. Its effectiveness with endovascular stents remains unknown.
Novel amphiphilic Dextran esters with antimicrobial activity
Int J Biol Macromol 2020 May 1;150:746-755.PMID:32035962DOI:10.1016/j.ijbiomac.2020.02.021.
New amphiphilic Dextran esters were obtained by polysaccharide functionalization with different substituted 1,2,3-triazoles-4-carboxylic acid via in situ activation with N, N'-carbonyldiimidazole. Nitrogen-containing heterocyclic derivatives were achieved by copper(I)-catalyzed cycloaddition reaction between organic azides and ethyl propiolate. Structural characteristics of the compounds were studied by elemental analysis, Fourier transform infrared and nuclear magnetic resonance spectroscopy (1H and 13C-NMR). Thermogravimetric analysis, differential scanning calorimetry and wide-angle X-ray diffraction were used for esters characterization. Properties of polymeric self-associates, formed in aqueous solution, were studied by dynamic light scattering and transmission electron microscopy. The critical aggregation concentration values for Dextran esters, determined by fluorescence spectroscopy, were in the range of 4.1-9.5 mg/dL. Antimicrobial activity, investigated for some of the polymers by disc-diffusion method, pointed out that polysaccharide esters were active.