D-Galacturonic acid (hydrate)
(Synonyms: D-半乳糖醛酸) 目录号 : GC38324
A monosaccharide
Cas No.:91510-62-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
D-Galacturonic acid is a monosaccharide and the major component of pectin.1 It is formed from glucose in a multi-step process in which uridine-5'-diphosphoglucuronic acid is epimerized to UDP-galacturonic acid, from which D-galacturonic acid can be oligomerized to form pectin or metabolized to L-ascorbic acid , L-galactonic acid, galactaric acid, or D-(+)-xylose .1,2 D-Galacturonic acid (200, 400, and 800 mg/kg) increases body weight and reduces intestinal mucosal permeability in a rat model of iodoacetamide-induced functional dyspepsia.3
1.Gu, X., and Bar-Peled, M.The biosynthesis of UDP-galacturonic acid in plants. Functional cloning and characterization of Arabidopsis UDP-D-glucuronic acid 4-epimerasePlant Physiol.136(4)4256-4264(2004) 2.Loewus, F.A., and Kelly, S.The metabolism of D-galacturonic acid and its methyl ester in the detached ripening strawberryArch. Biochem. Biophys.95(3)483-493(1961) 3.Wu, Y.-Y., Zhong, Z.-S., Ye, Z.-H., et al.D-galacturonic acid ameliorates the intestinal mucosal permeability and inflammation of functional dyspepsia in ratsAnn. Palliat. Med.10(1)538-548(2021)
| Cas No. | 91510-62-2 | SDF | |
| 别名 | D-半乳糖醛酸 | ||
| Canonical SMILES | O=C[C@@H]([C@H]([C@H]([C@@H](C(O)=O)O)O)O)O.O | ||
| 分子式 | C6H12O8 | 分子量 | 212.15 |
| 溶解度 | Water: 62.5 mg/mL (294.60 mM) | 储存条件 | Store at RT |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.7136 mL | 23.5682 mL | 47.1365 mL |
| 5 mM | 0.9427 mL | 4.7136 mL | 9.4273 mL |
| 10 mM | 0.4714 mL | 2.3568 mL | 4.7136 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Chemical and functional properties of cell wall polymers from two cherry varieties at two developmental stages
Carbohydr Polym 2013 Jan 30;92(1):830-41.PMID:23218373DOI:10.1016/j.carbpol.2012.09.091.
The cell wall polysaccharides of Regina and Sunburst cherry varieties at two developmental stages were extracted sequentially, and their changes in monosaccharide composition and functional properties were studied. The loosely-attached pectins presented a lower D-Galacturonic acid/rhamnose ratio than ionically-bound pectins, as well as lower thickening effects of their respective 2% aqueous solution: the lowest Newtonian viscosity and shear rate dependence during the pseudoplastic phase. The main constituents of the cell wall matrix were covalently bound pectins (probably through diferulate cross-linkings), with long arabinan side chains at the RG-I cores. This pectin domain was also anchored into the XG-cellulose elastic network. Ripening occurred with a decrease in the proportion of HGs, water extractable GGM and xylogalacturonan, and with a concomitant increase in neutral sugars. Ripening was also associated with higher viscosities and thickening effects, and to larger distribution of molecular weights. The highest firmness and compactness of Regina cherry may be associated with its higher proportion of calcium-bound HGs localized in the middle lamellae of cell walls, as well as to some higher molar proportion of NS (Rha and Ara) in covalently bound pectins. These pectins showed significantly better hydration properties than hemicellulose and cellulose network. Chemical composition and functional properties of cell wall polymers were dependent on cherry variety and ripening stage, and helped explain the contrasting firmness of Regina and Sunburst varieties.
Residue specific hydration of primary cell wall potato pectin identified by solid-state 13C single-pulse MAS and CP/MAS NMR spectroscopy
Biomacromolecules 2011 May 9;12(5):1844-50.PMID:21462966DOI:10.1021/bm2001928.
Hydration of rhamnogalacturonan-I (RG-I) derived from potato cell wall was analyzed by (13)C single-pulse (SP) magic-angle-spinning (MAS) and (13)C cross-polarization (CP) MAS nuclear magnetic resonance (NMR) and supported by (2)H SP/MAS NMR experiments. The study shows that the arabinan side chains hydrate more readily than the galactan side chains and suggests that the overall hydration properties can be controlled by modifying the ratio of these side chains. Enzymatic modification of native (NA) RG-I provided samples with reduced content of arabinan (sample DA), galactan (sample DG), or both side chains (sample DB). Results of these samples suggested that hydration properties were determined by the length and character of the side chains. NA and DA exhibited similar hydration characteristics, whereas DG and DB were difficult to hydrate because of the less hydrophilic properties of the rhamnose-galacturonic acid (Rha-GalA) backbone in RG-I. Potential food ingredient uses of RG-I by tailoring of its structure are discussed.