Pyridoxylamine dihydrochloride
(Synonyms: 盐酸吡多胺; Pyridoxamine dihydrochloride) 目录号 : GC38366
A 4-methylamine form of vitamin B6
Cas No.:524-36-7
Sample solution is provided at 25 µL, 10mM.
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Pyridoxylamine is a 4-methylamine form of vitamin B6 that is converted to pyridoxal 5'-phosphate , the active form of vitamin B6, and an important cofactor for metabolism.1 It scavenges isoketals in cell-free assays and inhibits the formation of lysyl-levuglandin-lactam adducts in dazoxiben-stimulated isolated human platelets when used at concentrations of 0.1 and 1 mM.2 Pyridoxylamine (1 g/L in the drinking water) inhibits the development of acellular capillaries and accumulation of Nε-(1-carboxymethyl)-L-lysine in the retina in a rat model of diabetes induced by streptozotocin .3 It reverses STZ-induced deficits in the novel object recognition task in a rat model of diabetes when administered in the drinking water at concentrations of 0.4 and 1 g/L.4
1.Kohlmeier, M.Water-soluble vitamins and nonnutrientsNutrient metabolism567-671(2015) 2.Davies, S.S., Brantley, E.J., Voziyan, P.A., et al.Pyridoxylamine analogues scavenge lipid-derived γ-ketoaldehydes and protect against H2O2-mediated cytotoxicityBiochemistry45(51)(2006) 3.Stitt, A., Gardiner, T.A., Alderson, N.L., et al.The AGE inhibitor Pyridoxylamine inhibits development of retinopathy in experimental diabetesDiabetes51(9)2826-2832(2002) 4.Kassab, S., Begley, P., Church, S.J., et al.Cognitive dysfunction in diabetic rats is prevented by Pyridoxylamine treatment. A multidisciplinary investigationMol. Metab.28107-119(2019)
| Cas No. | 524-36-7 | SDF | |
| 别名 | 盐酸吡多胺; Pyridoxamine dihydrochloride | ||
| Canonical SMILES | OCC1=C(CN)C(O)=C(C)N=C1.[H]Cl.[H]Cl | ||
| 分子式 | C8H14Cl2N2O2 | 分子量 | 241.11 |
| 溶解度 | DMSO : 120 mg/mL (497.70 mM; Need ultrasonic) Water : 120 mg/mL (497.70 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.1475 mL | 20.7374 mL | 41.4748 mL |
| 5 mM | 0.8295 mL | 4.1475 mL | 8.295 mL |
| 10 mM | 0.4147 mL | 2.0737 mL | 4.1475 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet