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Euscaphic acid Sale

(Synonyms: 野鸦椿酸) 目录号 : GC38392

A triterpene with diverse biological activities

Euscaphic acid Chemical Structure

Cas No.:53155-25-2

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1mg
¥1,170.00
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5mg
¥3,420.00
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Sample solution is provided at 25 µL, 10mM.

Description

Euscaphic acid is a triterpene that has been found in R. alceaefolius and has diverse biological activities.1,2,3 It inhibits the proliferation of CNE-1 and C666-1 nasopharyngeal carcinoma cells when used at concentrations of 5 and 10 ?g/ml.1 Euscaphic acid inhibits acetylcholinesterase (AChE; IC50 = 35.9 ?M) and α-glucosidase (IC50 = 24.9 ?M).2 It reduces the production of nitric oxide (NO) and levels of inducible nitric oxide synthase (iNOS) and COX-2 in LPS-stimulated RAW 264.7 cells.3 Euscaphic acid (10 mg/kg) reduces serum IgE and IgG2a levels, ear tissue mast cell infiltration, and pruritis in a mouse model of difluoroethane- and 2,4-dinitrochlorobenzene-induced atopic dermatitis.4

1.Dai, W., Dong, P., Liu, J., et al.Euscaphic acid inhibits proliferation and promotes apoptosis of nasopharyngeal carcinoma cells by silencing the PI3K/AKT/mTOR signaling pathwayAm. J. Transl. Res.11(4)2090-2098(2019) 2.Ado, M.A., Maulidiani, M., Ismail, I.S., et al.Acetylcholinesterase and α-glucosidase inhibitory compounds from Callicarpa maingayiNat. Prod. Res.35(17)2992-2996(2021) 3.Kim, I.-T., Ryu, S., Shin, J.-S., et al.Euscaphic acid isolated from roots of Rosa rugosa inhibits LPS-induced inflammatory responses via TLR4-mediated NF-κB inactivation in RAW 264.7 macrophagesJ. Cell. Biochem.113(6)1936-1946(2012) 4.Jeong, N.-H., Lee, S., Choi, Y.-A., et al.Inhibitory effects of euscaphic acid in the atopic dermatitis model by reducing skin inflammation and intense pruritusInflammation45(4)1680-1691(2022)

化学性质

Cas No. 53155-25-2 SDF
别名 野鸦椿酸
Canonical SMILES OC([C@]12[C@]([C@](O)([C@H](C)CC2)C)([H])C3=CC[C@@]([C@@]4([C@@](C(C)([C@H](O)[C@H](O)C4)C)([H])CC5)C)([H])[C@]5(C)[C@]3(C)CC1)=O
分子式 C30H48O5 分子量 488.7
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.0462 mL 10.2312 mL 20.4625 mL
5 mM 0.4092 mL 2.0462 mL 4.0925 mL
10 mM 0.2046 mL 1.0231 mL 2.0462 mL
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