Euscaphic acid
(Synonyms: 野鸦椿酸) 目录号 : GC38392
A triterpene with diverse biological activities
Cas No.:53155-25-2
Sample solution is provided at 25 µL, 10mM.
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Euscaphic acid is a triterpene that has been found in R. alceaefolius and has diverse biological activities.1,2,3 It inhibits the proliferation of CNE-1 and C666-1 nasopharyngeal carcinoma cells when used at concentrations of 5 and 10 ?g/ml.1 Euscaphic acid inhibits acetylcholinesterase (AChE; IC50 = 35.9 ?M) and α-glucosidase (IC50 = 24.9 ?M).2 It reduces the production of nitric oxide (NO) and levels of inducible nitric oxide synthase (iNOS) and COX-2 in LPS-stimulated RAW 264.7 cells.3 Euscaphic acid (10 mg/kg) reduces serum IgE and IgG2a levels, ear tissue mast cell infiltration, and pruritis in a mouse model of difluoroethane- and 2,4-dinitrochlorobenzene-induced atopic dermatitis.4
1.Dai, W., Dong, P., Liu, J., et al.Euscaphic acid inhibits proliferation and promotes apoptosis of nasopharyngeal carcinoma cells by silencing the PI3K/AKT/mTOR signaling pathwayAm. J. Transl. Res.11(4)2090-2098(2019) 2.Ado, M.A., Maulidiani, M., Ismail, I.S., et al.Acetylcholinesterase and α-glucosidase inhibitory compounds from Callicarpa maingayiNat. Prod. Res.35(17)2992-2996(2021) 3.Kim, I.-T., Ryu, S., Shin, J.-S., et al.Euscaphic acid isolated from roots of Rosa rugosa inhibits LPS-induced inflammatory responses via TLR4-mediated NF-κB inactivation in RAW 264.7 macrophagesJ. Cell. Biochem.113(6)1936-1946(2012) 4.Jeong, N.-H., Lee, S., Choi, Y.-A., et al.Inhibitory effects of euscaphic acid in the atopic dermatitis model by reducing skin inflammation and intense pruritusInflammation45(4)1680-1691(2022)
| Cas No. | 53155-25-2 | SDF | |
| 别名 | 野鸦椿酸 | ||
| Canonical SMILES | OC([C@]12[C@]([C@](O)([C@H](C)CC2)C)([H])C3=CC[C@@]([C@@]4([C@@](C(C)([C@H](O)[C@H](O)C4)C)([H])CC5)C)([H])[C@]5(C)[C@]3(C)CC1)=O | ||
| 分子式 | C30H48O5 | 分子量 | 488.7 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.0462 mL | 10.2312 mL | 20.4625 mL |
| 5 mM | 0.4092 mL | 2.0462 mL | 4.0925 mL |
| 10 mM | 0.2046 mL | 1.0231 mL | 2.0462 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet