Diosgenin glucoside
(Synonyms: 延龄草苷) 目录号 : GC38408
A steroidal saponin with diverse biological activities
Cas No.:14144-06-0
Sample solution is provided at 25 µL, 10mM.
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Disogluside is a steroidal saponin that has been found in T. tschonoskii and has diverse biological activities.1,2,3,4,5 It is an inhibitor of UDP-glucuronosyltransferase (UGT) isoform UGT1A4 (IC50 = 10.5 ?M).1 Disogluside is cytotoxic to K562 chronic myeloid leukemia (CML) cells (IC50 = ~7.5 ?M).2 It improves neurological function and decreases neuronal damage in a rat model of spinal cord injury when administered at a dose of 100 mg/kg.3 Disogluside (50 mg/kg) decreases serum levels of glucose, insulin, and triglycerides in diabetic db/db mice.4 It reduces serum malondialdehyde (MDA) levels and stomach myeloperoxidase (MPO) activity in a mouse model of ethanol-induced gastric ulcers.5
1.Xu, M., Dong, P., Tian, X., et al.Drug interaction study of natural steroids from herbs specifically toward human UDP-glucuronosyltransferase (UGT) 1A4 and their quantitative structure activity relationship (QSAR) analysis for predictionPharmacol. Res.110139-150(2016) 2.Liu, M.-J., Wang, Z., Ju, Y., et al.The mitotic-arresting and apoptosis-inducing effects of diosgenyl saponins on human leukemia cell linesBiol. Pharm. Bull.27(7)1059-1065(2004) 3.Chen, X.-B., Wang, Z.-L., Yang, Q.-Y., et al.Diosgenin glucoside protects against spinal cord injury by regulating autophagy and alleviating apoptosisInt. J. Mol. Sci.19(8)2274(2018) 4.Wu, Y., Ye, F., Lu, Y., et al.Diosgenin glucoside protects against myocardial injury in diabetic mice by inhibiting RIP140 signalingAm. J. Transl. Res.10(11)3742-3749(2018) 5.Chen, T., Jiang, W., Zhang, H., et al.Protective effect of trillin against ethanol-induced acute gastric lesions in an animal modelRSC Adv.620081-20088(2016)
| Cas No. | 14144-06-0 | SDF | |
| 别名 | 延龄草苷 | ||
| Canonical SMILES | C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@]34CC[C@@H](C)CO4)([H])C[C@@]1([H])[C@@](CC=C5[C@@]6(CC[C@H](O[C@]([C@@H]([C@@H](O)[C@@H]7O)O)([H])O[C@@H]7CO)C5)C)([H])[C@]6([H])CC2 | ||
| 分子式 | C33H52O8 | 分子量 | 576.76 |
| 溶解度 | DMSO : 125 mg/mL (216.73 mM; Need ultrasonic) | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.7338 mL | 8.6691 mL | 17.3382 mL |
| 5 mM | 0.3468 mL | 1.7338 mL | 3.4676 mL |
| 10 mM | 0.1734 mL | 0.8669 mL | 1.7338 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet