Isocorydine

Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities.^1,2,3,4,5 It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 ?M.² Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC₅₀ value of 12.6 ?M.³ It is cytotoxic to A549 lung cancer cells (IC₅₀ = 197.7 ?M), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC₅₀s = 161.3, 148, 262.2, and 254.1 ?g/ml, respectively).^4,5 Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.⁵

1.Bhakuni, D.S., Tewari, S., and Dhar, M.M.Aporphine alkaloids of Annona squamosaPhytochemistry11(5)1819-1822(1972) 2.Zhao, Y.-Q., Li, G.-R., Zhang, D.-Z., et al.Effects of isocorydine on action potentials in isolated canine purkinje fibers and ventricular musclesJ. Mol. Cell. Cardiol.12(4)324-327(1991) 3.Jiang, Q.-S., Huang, X.-N., Sun, A.-S., et al.Relation of vasodilative action of isocorydine to cyclic nucleotidesChi. J. Pharm. Toxicol.15(4)251-255(2011) 4.Zhong, M., Liu, Y., Liu, J., et al.Isocorydine derivatives and their anticancer activitiesMolecules19(8)12099-12115(2014) 5.Pan, J.-X., Chen, G., Li, J.-J., et al.Isocorydine suppresses doxorubicin-induced epithelial-mesenchymal transition via inhibition of ERK signaling pathways in hepatocellular carcinomaAm. J. Cancer Res.8(1)154-164(2018)