Fangchinoline
(Synonyms: 防己诺林碱) 目录号 : GC38437
An alkaloid with diverse biological activities
Cas No.:436-77-1
Sample solution is provided at 25 µL, 10mM.
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Fangchinoline is an alkaloid that has been found in S. tetrandrae and has diverse biological activities, including anti-inflammatory, neuroprotective, and anticancer properties.1,2,3 It inhibits the activity of sheep COX and decreases IL-6-induced proliferation of MH60 mouse hybridoma cells with IC50 values of 129 and 3.7 ?M, respectively.1 Fangchinoline (1 and 10 ?M) reduces cyanide-induced increases in secreted glutamate levels and cell death in primary neonatal rat cerebellar granule neurons.2 It decreases proliferation of PC3 human prostate cancer cells by 63 and 86% when used at concentrations of 20 and 30 ?M, respectively.3 Fangchinoline reduces tumor growth in a PC3 mouse xenograft model when administered at a dose of 5 mg/kg per day for 12 days.
1.Choi, H.S., Kim, H.S., Min, K.R., et al.Anti-inflammatory effects of fangchinoline and tetrandrineJ. Ethnopharmacol.69(2)173-179(2000) 2.Cho, S.O., and Seong, Y.H.Protective effect of fangchinoline on cyanide-induced neurotoxicity in cultured rat cerebellar granule cellsArch. Pharm. Res.25(3)349-356(2002) 3.Wang, C.D., Huang, J.G., Gao, X., et al.Fangchinoline induced G1/S arrest by modulating expression of p27, PCNA, and cyclin D in human prostate carcinoma cancer PC3 cells and tumor xenograftBiosci. Biotechnol. Biochem.74(3)488-493(2010)
| Cas No. | 436-77-1 | SDF | |
| 别名 | 防己诺林碱 | ||
| Canonical SMILES | OC1=C(OC2=CC([C@]3([H])CC(C=C4)=CC=C4O5)=C(CCN3C)C=C2OC)C([C@](N6C)([H])CC7=CC=C(OC)C5=C7)=C(CC6)C=C1OC | ||
| 分子式 | C37H40N2O6 | 分子量 | 608.72 |
| 溶解度 | DMSO: 50 mg/mL (82.14 mM) | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.6428 mL | 8.214 mL | 16.4279 mL |
| 5 mM | 0.3286 mL | 1.6428 mL | 3.2856 mL |
| 10 mM | 0.1643 mL | 0.8214 mL | 1.6428 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet