SNPB
目录号 : GC38549
SNPB 是一种用于制备抗体偶联药物 (ADC) 的可切割连接桥。
Cas No.:663598-85-4
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
SNPB is a cleavable linker that is used for making antibody-drug conjugate (ADC).
[1]. Qiming Chen, et al. Anti-integrin immunoconjugates, methods and uses. WO2006062779A2.
| Cas No. | 663598-85-4 | SDF | |
| Canonical SMILES | O=C(ON1C(CCC1=O)=O)CCCSSC2=NC=C([N+]([O-])=O)C=C2 | ||
| 分子式 | C13H13N3O6S2 | 分子量 | 371.39 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.6926 mL | 13.4629 mL | 26.9259 mL |
| 5 mM | 0.5385 mL | 2.6926 mL | 5.3852 mL |
| 10 mM | 0.2693 mL | 1.3463 mL | 2.6926 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Structural and Superconducting Proximity Effect of SNPB Bimetallic Nanoalloys
Nanomaterials (Basel) 2022 Dec 5;12(23):4323.PMID:36500944DOI:10.3390/nano12234323.
We report the superconducting properties between a conventional strong-coupled Pb and weak-coupled Sn superconductor. A series of SnrPb1-r nanoalloys with various compositions r were synthesized, and their superconducting properties were measured using superconducting quantum interference devices (SQUIDs) magnetometer. Our results reveal a superconducting proximity effect (SPE) between immiscible Sn and Pb granules in the range of r = 0.2~0.9, as a weak superconducting coupling can be established with the coexistence of phonon hardening and increased Ginzburg-Landau coherence length. Furthermore, our results provide new insights into improving the study of the superconducting proximity effect introduced by Sn doping.
Quantum spin Hall effect in two-dimensional hydrogenated SNPB alloy films
Phys Chem Chem Phys 2018 Apr 4;20(14):9610-9615.PMID:29578235DOI:10.1039/c8cp01015c.
Using first-principles calculations, we studied the geometric and band structures of 20 possible configurations of buckled hydrogenated SNPB alloy (SnxPb8-xH8) films. The configurations are topological insulators (TIs) when x ≥ 1. When x increases from 1 to 7, the band gap increases from 0.087 eV to 0.98 eV. The topological characteristics are suggested by s-pxy band inversion and confirmed by helical edge states, which are time-reversal symmetry protected. According to spin-orbit coupling (SOC) analysis results, we draw the conclusion that the Pb atoms have greater SOC strength than the Sn atoms, so when the number ratio of Pb and Sn atoms is greater than 1/12 the SOC strength is large enough to trigger the band inversion between the s and pxy orbitals, causing the SNPB alloy film to turn into a topological insulator (TI) from a normal band insulator (NI). We give a simple rule for the topological criterion of hydrogenated SNPB alloy films by comparing the ratio of Pb and Sn atoms. This would provide a useful reference for the design of topological devices based on NI-TI hetero-junctions for experiments.
Enhanced Device Performance with Passivation of the TiO2 Surface Using a Carboxylic Acid Fullerene Monolayer for a SNPB Perovskite Solar Cell with a Normal Planar Structure
ACS Appl Mater Interfaces 2020 Apr 15;12(15):17776-17782.PMID:32204584DOI:10.1021/acsami.0c01411.
Research on tin-lead (SNPB) perovskite solar cells (PSCs) has gained popularity in recent years because of their low band gap, which could be applied to tandem solar cells. However, most of the work is based on inverted PSCs using PEDOT:PSS as the hole-transport layer as normal-structure PSCs show lower efficiency. In this work, the reason behind the low efficiency of normal-structure SNPB PSCs is elucidated and surface passivation has been tested as a method to overcome the problem. In the case of normal PSCs, at the interface between the titania layer and SNPB perovskite, there are many carrier traps observed originating from Ti-O-Sn bonds. In order to avoid the direct contact between titania and the SNPB perovskite layer, the titania surface is passivated with carboxylic acid C60 resulting in an efficiency increase from 5.14 to 7.91%. This will provide a direction of enhancing the efficiency of the normal-structure SNPB PSCs through heterojunction engineering.
Mass spectrometric and computational study of SNPB in the gas phase
J Chem Phys 2005 Jan 1;122(1):14303.PMID:15638655DOI:10.1063/1.1825997.
The SNPB molecule has been identified in a Knudsen effusion mass spectrometry experiment. The direct dissociation reaction and two isomolecular exchange reactions involving the Sn(2) and Pb(2) molecules have been studied, in the 1426-1705 K range of temperatures, using both second and third law procedures. The D(degree)0(SNPB,g) has been derived, for the first time, as (122.6+/-4.0) kJ mol(-1). Density functional and ab initio calculations up to the coupled clusters level of theory were also performed. In addition, the anion dissociation energy D(degree)0(SNPB(-),g) of (179.2+/-4.2) kJ mol(-1) was determined using the D(degree)0(SNPB,g) mass spectrometric value derived in this investigation and literature data.
Microstructure and Grain Orientation Evolution in SNPB/SnAgCu Interconnects Under Electrical Current Stressing at Cryogenic Temperature
Materials (Basel) 2019 May 15;12(10):1593.PMID:31096663DOI:10.3390/ma12101593.
Electromigration was characterized at the cathode Cu/solder interface-without the effect of Joule heating-by employing scanning electron microscopy (SEM) and electron backscatter diffraction (EBSD) analyses. Rapid (Cux,Ni1-x)6Sn5 intermetallic compound (IMC) growth was observed at the anomalous region at the cathode end due to the effect of current crowding. The abnormal isotropic diffusion and parallel distribution of Pb were characterized in an ultra-low temperature environment in a monocrystalline structure stressed at -196 °C. The interesting results were attributed to crystallographic transformation due to the simultaneous effect of cryogenic and electrical stressing. The diffusion behavior of Pb atoms in face-centered cubic lattices performed isomorphism. As a result, Pb atoms of the bump gathered at the high-energy grain boundaries by diffusing through the face-centered cubic lattices around the long grain boundary, eventually forming a long-range distribution and accumulation of Pb elements. Our study may provide understanding of cryogenic electromigration evolution of the Cu/solder interface and provide visual data for abnormal lattice transformation at the current stressing.