Deoxypodophyllotoxin

Deoxypodophyllotoxin (DPT) is a flavolignan that has been found in J. sabina and has diverse biological activities.^1,2,3,4,5 It inhibits tubulin polymerization in a cell-free assay when used at a concentration of 50 nM.¹ DPT in also inhibits COX-2 and 5-lipoxygenase (5-LO) in isolated mouse bone marrow-derived mast cells stimulated with KL, IL-10, and LPS (IC₅₀s = 1.89 and 0.37 ?M, respectively).² It reduces viral yield in the supernatant of MRC-5 cells infected with herpes simplex virus 1 (HSV-1) or HSV-2 when used at a concentration of 0.02 ?g/ml.³ DPT inhibits aggregation of rabbit platelets induced by platelet-activating factor (PAF), collagen, or arachidonic acid in a concentration-dependent manner.⁴ It induces mortality in P. rapae fifth instar larvae (LC₅₀ = 0.02 g/L).⁵ DPT (70 ?g/kg) reduces tumor growth in a CT26 murine colon cancer model.¹

1.Gamage, C.D.B., Park, S.-Y., Yang, Y., et al.Deoxypodophyllotoxin exerts anti-cancer effects on colorectal cancer cells through induction of apoptosis and suppression of tumorigenesisInt. J. Mol. Sci.20(11)2612(2019) 2.Lee, S.H., Son, M.J., Ju, H.K., et al.Dual inhibition of cyclooxygenases-2 and 5-lipoxygenase by deoxypodophyllotoxin in mouse bone marrow-derived mast cellsBiol. Pharm. Bull.27(6)786-788(2004) 3.Sudo, K., Konno, K., Shigeta, S., et al.Inhibitory effects of podophyllotoxin derivatives on herpes simplex virus replicationAntivir. Chem. Chemother.9(3)263-267(1998) 4.Chen, J.-J., Chang, Y.-L., Teng, C.-M., et al.Anti-platelet aggregation alkaloids and lignans from Hernandia nymphaeifoliaPlanta Med.66(3)251-256(1999) 5.Gao, R., Gao, C., Tian, X., et al.Insecticidal activity of deoxypodophyllotoxin, isolated from Juniperus sabina L, and related lignans against larvae of Pieris rapae LPest Manag. Sci.60(11)1131-1136(2004)