Nepodin
(Synonyms: 羊蹄素,Musizin) 目录号 : GC38567
A naphthol with diverse biological activities
Cas No.:3785-24-8
Sample solution is provided at 25 µL, 10mM.
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Nepodin is a naphthol that has been found in Rumex and has diverse biological activities.1,2,3,4 It inhibits COX-1 and COX-2 in vitro (IC50s = 27.43 and 32.28 μM, respectively).1 Nepodin inhibits C. albicans and S. aureus biofilm formation in a concentration-dependent manner when used at concentrations ranging from 1 to 10 μM.2 It is active against chloroquine-sensitive and -resistant P. falciparum strains (IC50s = 0.74 and 0.79 μg/ml for strains 3D7 and S20, respectively).3 Nepodin (250 mg/kg) suppresses parasitemia and increases survival time in a mouse model of P. berghei infection. It also increases skeletal muscle phosphorylation of AMPK, reduces serum and hepatic triglyceride and cholesterol levels, and improves insulin resistance in db/db diabetic mice.4
1.Grover, J., Kumar, V., Singh, V., et al.Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitorsEur. J. Med. Chem.8047-56(2014) 2.Lee, J.H., Kim, Y.G., Khadke, S.K., et al.Inhibition of biofilm formation by Candida albicans and polymicrobial microorganisms by nepodin via hyphal-growth suppressionACS Infect. Dis.5(7)1177-1187(2019) 3.Lee, K.H., and Rhee, K.H.Antimalarial activity of nepodin isolated from Rumex crispusArch. Pharm. Res.36(4)430-435(2013) 4.Ha, B.G., Yonezawa, T., Son, M.J., et al.Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivoBiofactors40(4)436-447(2014)
| Cas No. | 3785-24-8 | SDF | |
| 别名 | 羊蹄素,Musizin | ||
| Canonical SMILES | CC(C1=C(C)C=C2C=CC=C(O)C2=C1O)=O | ||
| 分子式 | C13H12O3 | 分子量 | 216.23 |
| 溶解度 | DMSO : 125 mg/mL (578.09 mM; Need ultrasonic) | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 4.6247 mL | 23.1235 mL | 46.2471 mL |
| 5 mM | 0.9249 mL | 4.6247 mL | 9.2494 mL |
| 10 mM | 0.4625 mL | 2.3124 mL | 4.6247 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet