Galgravin

Galgravin is a lignan that has been found in N. megapotamica and has diverse biological activities.^1,2,3,4 It inhibits the binding of platelet-activating factor (PAF) to isolated rabbit platelet plasma membranes (IC₅₀ = 4.5 ?M).¹ Galgravin (3-100 ?M) inhibits osteoclast formation induced by RANKL and macrophage colony-stimulating factor (M-CSF) in mouse bone marrow-derived macrophages.² It protects against cytotoxicity induced by human amyloid-β (25-35) (Aβ (25-35); Item No. 24155) in primary rat hippocampal neurons when used at a concentration of 10 ?M.³ Galgravin (20 mg/kg) reduces acetic acid-induced abdominal constrictions in mice and carrageenan-induced paw edema in rats.⁴

1.Biftu, T., Gamble, N.F., Doebber, T., et al.Conformation and activity of tetrahydrofuran lignans and analogues as specific platelet activating factor antagonistsJ. Med. Chem.29(10)1917-1921(1986) 2.Asai, M., Lee, J.-W., Itakura, Y., et al.Effects of veraguensin and galgravin on osteoclast differentiation and functionCytotechnology64(3)315-322(2012) 3.Zhai, H., Inoue, T., Moriyama, M., et al.Neuroprotective effects of 2,5-diaryl-3,4-dimethyltetrahydrofuran neolignansBiol. Pharm. Bull.28(2)289-293(2005) 4.da Silva Filho, A.A., Andrade e Silva, M.L., Carvalho, J.C.T., et al.Evaluation of analgesic and anti-inflammatory activities of Nectandra megapotamica (Lauraceae) in mice and ratsJ. Pharm. Pharmacol.56(9)1179-1184(2004)